Recent technologies have resulted in an explosion of information concerning the
cytochrome P‐450 isoenzymes and increased awareness of life‐threatening interactions' …

Synopsis Venlafaxine is a phenylethylamine derivative which facilitates neurotransmission
in the brain by blocking presynaptic reuptake of serotonin (5-hydroxytryptamine; 5-HT) and …

Page 1 INTRODUCTION TO DRUG METABOLISM Second edition G. Gordon Gibson and
Paul Skett H SPRINGER-SCIENCE+BUSINESS MEDIA, BV Page 2 Introduction to Drug …

The present study identifies the specific human cytochrome P-450 (CYP) enzymes involved
in hydroxylation leading to activation of the anticancer drug cyclophosphamide and its …

Sertraline is a naphthalenamine derivative with the predominant pharmacological action of
inhibiting presynaptic reuptake of serotonin from the synaptic cleft. It was initially marketed …

Objective: This review evaluates the in vitro and in vivo evidence for inhibition of cytochrome
P450 enzymes by the newer antidepressant's and provides clinical recommendations Ior …

A history of depression or depressive symptomatology has been reported in up to two‐thirds
of patients with medically intractable epilepsy, whereas community studies have …

A feature common to all selective serotonin reuptake inhibitors (SSRIs) is that they are
believed to act as antidepressant drugs because of their ability to reversibly block the …

The selective serotonin reuptake inhibitors (SSRIs) may occasionally induce extrapyramidal
side-effects (EPS) and/or akathisia. This maybe a consequence of serotonergically …

Genetic and environmental factors contribute to a wide inter-and intraindividual variability in
drug metabolism. Among the environmental factors that may influence drug metabolism, the …