Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in
response to cellular damage and stress. Senescent cells (SnCs) can develop a …

Aging is the progressive loss of organ and tissue function over time. Growing older is
positively linked to cognitive and biological degeneration such as physical frailty …

Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of
differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under …

Aging is the major risk factor for many human diseases. In vitro studies have demonstrated
that cellular reprogramming to pluripotency reverses cellular age, but alteration of the aging …

Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

Aging is an inevitable outcome of life, characterized by progressive decline in tissue and
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …

Over the past decade, a growing number of studies have revealed that progressive changes
to epigenetic information accompany aging in both dividing and nondividing cells …

Biological aging is associated with a reduction in the reparative and regenerative potential
in tissues and organs. This reduction manifests as a decreased physiological reserve in …

Senescent cells accumulate with age in vertebrates and promote aging largely through their
senescence‐associated secretory phenotype (SASP). Many types of stress induce …

Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …