A growing amount of evidence suggests that ubiquitination and deubiquitination of
programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) play crucial roles in the …

The STUB1 gene (STIP1 homology and U-box-containing protein 1), located at 16q13. 3,
encodes the CHIP (carboxyl terminus of Hsc70-interacting protein), an essential E3 ligase …

Abstract YTH domain family 2 (YTHDF2) is the first identified N6‐methyladenosine (m6A)
reader that regulates the status of mRNA. It has been reported that overexpressed YTHDF2 …

The immune checkpoint molecules programmed cell death receptor 1 (PD-1) and
programmed death ligand 1 (PD-L1) are one of the most promising targets for tumor …

Introduction In view of other candidate proteins from the cathepsin family of proteases
holding great potential in being targeted during cancer therapy, the importance of Cathepsin …

Cathepsins (CTS) are mainly lysosomal acid hydrolases extensively involved in the
prognosis of different diseases, and having a distinct role in tumor progression by regulating …

Ovarian tumour domain-containing protein 3 (OTUD3), a key OTU (ovarian tumour protease)
family deubiquitylase, plays context-dependent roles in cancers. It suppresses …

Epithelial–mesenchymal transition (EMT) is a reversible cellular program that transiently
places epithelial (E) cells into pseudo-mesenchymal (M) cell states. The malignant …

Several studies show that triple-negative breast cancer (TNBC) patients have the lowest
vitamin D concentration among all breast cancer types, suggesting that this vitamin may …

The carboxy-terminus of Hsp70-interacting protein (CHIP) is a ubiquitin ligase and co-
chaperone belonging to Ubox family that plays a crucial role in the maintenance of cellular …