Updates in bile acid-bioactive molecule conjugates and their applications
Bile acid conjugates are emerging as important chemical resources due to their low cost and
wide availability of bile acids, making them privileged molecules in drug carrier systems and …
wide availability of bile acids, making them privileged molecules in drug carrier systems and …
Insights into the chemistry and therapeutic potential of acrylonitrile derivatives
O Unsal Tan, M Zengin - Archiv der Pharmazie, 2022 - Wiley Online Library
Acrylonitrile is a fascinating scaffold widely found in many natural products, drugs, and drug
candidates with various biological activities. Several drug molecules such as entacapone …
candidates with various biological activities. Several drug molecules such as entacapone …
Bile acid conjugates with anticancer activity: most recent research
ML Navacchia, E Marchesi, D Perrone - Molecules, 2020 - mdpi.com
The advantages of a treatment modality that combines two or more therapeutic agents in
cancer therapy encourages the study of hybrid functional compounds for pharmacological …
cancer therapy encourages the study of hybrid functional compounds for pharmacological …
Synthesis of bile acid-thiadiazole conjugates as antibacterial and antioxidant agents
S Patel, S Mishra - Steroids, 2023 - Elsevier
The synthesis, characterization, and antibacterial and antioxidant activity of thiadiazole-
deoxycholic/lithocholic acid conjugates are described in this communication. The structures …
deoxycholic/lithocholic acid conjugates are described in this communication. The structures …
Bile Acid-conjugate as a Promising Anticancer Agent: Recent Progress
NV Rathod, S Mishra - Current Medicinal Chemistry, 2024 - benthamdirect.com
Bile acids have outstanding chemistry due to their amphiphilic nature and have received a
lot of interest in the last few decades in the fields of biomedicine, pharmacology, and …
lot of interest in the last few decades in the fields of biomedicine, pharmacology, and …
Comparative analysis of the compatibility effects of Danggui-Sini Decoction on a blood stasis syndrome rat model using untargeted metabolomics
JX Wu, H Zheng, X Yao, XW Liu, HJ Zhu, CL Yin… - … of Chromatography B, 2019 - Elsevier
Abstract Danggui-Sini Decoction (DSD) is one of the most widely used traditional Chinese
medicine formulae (TCMF) for treating various diseases caused by cold coagulation and …
medicine formulae (TCMF) for treating various diseases caused by cold coagulation and …
The anticancer activity of bile acids in drug discovery and development
W Li, L Zou, S Huang, H Miao, K Liu, Y Geng… - Frontiers in …, 2024 - frontiersin.org
Bile acids (BAs) constitute essential components of cholesterol metabolites that are
synthesized in the liver, stored in the gallbladder, and excreted into the intestine through the …
synthesized in the liver, stored in the gallbladder, and excreted into the intestine through the …
Clickable conjugates of bile acids and nucleosides: Synthesis, characterization, in vitro anticancer and antituberculosis studies
A series of clickable bile acid-nucleosides conjugates linked directly or via amino acid linker
were synthesized, and characterized by spectroscopic techniques such as 1 H NMR, 13 C …
were synthesized, and characterized by spectroscopic techniques such as 1 H NMR, 13 C …
Bile-acid-appended triazolyl aryl ketones: Design, synthesis, in vitro anticancer activity and pharmacokinetics in rats
A library of bile-acid-appended triazolyl aryl ketones was synthesized and characterized by
detailed spectroscopic techniques such as 1H and 13C NMR, HRMS and HPLC. All the …
detailed spectroscopic techniques such as 1H and 13C NMR, HRMS and HPLC. All the …
Synthesis of modified bile acids via palladium-catalyzed C (sp 3)–H (hetero) arylation
A Pd (II)-catalyzed strategy for the diastereo-and regioselective (hetero) arylation of
unactivated C (sp3)–H bonds in bile acids is accomplished with aryl and heteroaryl iodides …
unactivated C (sp3)–H bonds in bile acids is accomplished with aryl and heteroaryl iodides …