Updates in bile acid-bioactive molecule conjugates and their applications

R Mishra, S Mishra - Steroids, 2020 - Elsevier
Bile acid conjugates are emerging as important chemical resources due to their low cost and
wide availability of bile acids, making them privileged molecules in drug carrier systems and …

Insights into the chemistry and therapeutic potential of acrylonitrile derivatives

O Unsal Tan, M Zengin - Archiv der Pharmazie, 2022 - Wiley Online Library
Acrylonitrile is a fascinating scaffold widely found in many natural products, drugs, and drug
candidates with various biological activities. Several drug molecules such as entacapone …

Bile acid conjugates with anticancer activity: most recent research

ML Navacchia, E Marchesi, D Perrone - Molecules, 2020 - mdpi.com
The advantages of a treatment modality that combines two or more therapeutic agents in
cancer therapy encourages the study of hybrid functional compounds for pharmacological …

Synthesis of bile acid-thiadiazole conjugates as antibacterial and antioxidant agents

S Patel, S Mishra - Steroids, 2023 - Elsevier
The synthesis, characterization, and antibacterial and antioxidant activity of thiadiazole-
deoxycholic/lithocholic acid conjugates are described in this communication. The structures …

Bile Acid-conjugate as a Promising Anticancer Agent: Recent Progress

NV Rathod, S Mishra - Current Medicinal Chemistry, 2024 - benthamdirect.com
Bile acids have outstanding chemistry due to their amphiphilic nature and have received a
lot of interest in the last few decades in the fields of biomedicine, pharmacology, and …

Comparative analysis of the compatibility effects of Danggui-Sini Decoction on a blood stasis syndrome rat model using untargeted metabolomics

JX Wu, H Zheng, X Yao, XW Liu, HJ Zhu, CL Yin… - … of Chromatography B, 2019 - Elsevier
Abstract Danggui-Sini Decoction (DSD) is one of the most widely used traditional Chinese
medicine formulae (TCMF) for treating various diseases caused by cold coagulation and …

The anticancer activity of bile acids in drug discovery and development

W Li, L Zou, S Huang, H Miao, K Liu, Y Geng… - Frontiers in …, 2024 - frontiersin.org
Bile acids (BAs) constitute essential components of cholesterol metabolites that are
synthesized in the liver, stored in the gallbladder, and excreted into the intestine through the …

Clickable conjugates of bile acids and nucleosides: Synthesis, characterization, in vitro anticancer and antituberculosis studies

DS Agarwal, VS Krishna, D Sriram, P Yogeeswari… - Steroids, 2018 - Elsevier
A series of clickable bile acid-nucleosides conjugates linked directly or via amino acid linker
were synthesized, and characterized by spectroscopic techniques such as 1 H NMR, 13 C …

Bile-acid-appended triazolyl aryl ketones: Design, synthesis, in vitro anticancer activity and pharmacokinetics in rats

DS Agarwal, S Mazumdar, KS Italiya, D Chitkara… - Molecules, 2021 - mdpi.com
A library of bile-acid-appended triazolyl aryl ketones was synthesized and characterized by
detailed spectroscopic techniques such as 1H and 13C NMR, HRMS and HPLC. All the …

Synthesis of modified bile acids via palladium-catalyzed C (sp 3)–H (hetero) arylation

SA Borade, S Naharwal, H Bhambri… - Organic & …, 2023 - pubs.rsc.org
A Pd (II)-catalyzed strategy for the diastereo-and regioselective (hetero) arylation of
unactivated C (sp3)–H bonds in bile acids is accomplished with aryl and heteroaryl iodides …