Brain tumors, although rare, contribute to distinct mortality and morbidity at all ages.
Although there are few therapeutic options for brain tumors, enhanced biological …

Meningiomas are the most the common primary brain tumors in adults, representing
approximately a third of all intracranial neoplasms. They classically are found to be more …

Intratumor heterogeneity underlies cancer evolution and treatment resistance, but targetable
mechanisms driving intratumor heterogeneity are poorly understood. Meningiomas are the …

Methylation at DNA, RNA and protein levels plays critical roles in many cellular processes
and is associated with diverse differentiation events, physiological activities and human …

The mutational landscape of meningioma has expanded following the use of the new
genetic sequencing approaches. Novel mutations have been characterized and reveal their …

Background Genomic studies of high-grade/progressive meningiomas have reported a
heterogeneous mutation spectrum, identifying few recurrently mutated genes. Most studies …

Meningiomas are the most common primary intracranial neoplasm. The current World
Health Organization (WHO) classification categorizes meningiomas based on …

Background There is a critical need for objective and reliable biomarkers of outcome in
meningiomas beyond WHO classification. Loss of H3K27me3 has been reported as a …

Although the majority of meningiomas are slow-growing and benign, atypical and anaplastic
meningiomas behave aggressively with a penchant for recurrence. Standard of care …

Oligodendrogliomas are defined at the molecular level by the presence of an IDH mutation
and codeletion of chromosomal arms 1p and 19q. In the past, case reports and small studies …