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Nanotherapeutics for pulmonary drug delivery: An emerging approach to overcome respiratory diseases
Pulmonary diseases pose an immense threat to global health. Several nanotherapeutics-
based approaches aimed to tackle pulmonary ailments in recent years. The current …
based approaches aimed to tackle pulmonary ailments in recent years. The current …
Recent advances in the understanding of alveolar flow
Understanding the dynamics of airflow in alveoli and its effect on the behavior of particle
transport and deposition is important for understanding lung functions and the cause of …
transport and deposition is important for understanding lung functions and the cause of …
[HTML][HTML] Nanoparticle transport and deposition in a heterogeneous human lung airway tree: An efficient one path model for CFD simulations
Understanding nano-particle inhalation in human lung airways helps targeted drug delivery
for treating lung diseases. A wide range of numerical models have been developed to …
for treating lung diseases. A wide range of numerical models have been developed to …
Towards whole-lung simulations of aerosol deposition: A model of the deep lung
In silico methods can be used to estimate regional deposition of inhaled aerosols in regions
of the lung that are inaccessible by direct measurements. Knowledge of deposited dose is …
of the lung that are inaccessible by direct measurements. Knowledge of deposited dose is …
[HTML][HTML] A critical analysis of the CFD-DEM simulation of pharmaceutical aerosols deposition in extra-thoracic airways
Recent advances in the characterization of the human respiratory system and in multi-phase
flow dynamics in complex geometries have led numerical simulations to play an expanding …
flow dynamics in complex geometries have led numerical simulations to play an expanding …
[HTML][HTML] A numerical study of the aerosol behavior in intra-acinar region of a human lung
D Ciloglu - Physics of Fluids, 2020 - pubs.aip.org
The determination of the particle dynamics in the human acinar airways having millions of
alveoli is critical in preventing potential health problems and delivering therapeutic particles …
alveoli is critical in preventing potential health problems and delivering therapeutic particles …
Inhalable spray-dried polycaprolactone-based microparticles of Sorafenib Tosylate with promising efficacy on A549 cells
The study developed and evaluated Sorafenib Tosylate (SRT)-loaded polymeric
microparticles (MPs) using biodegradable polymer polycaprolactone (PCL) as a potential …
microparticles (MPs) using biodegradable polymer polycaprolactone (PCL) as a potential …
VIVID: In Vivo End-to-End Molecular Communication Model for COVID-19
As an alternative to ongoing efforts for vaccine development, scientists are exploring novel
approaches to provide innovative therapeutics, such as nanoparticle-and stem cell-based …
approaches to provide innovative therapeutics, such as nanoparticle-and stem cell-based …
Fluid-structure interaction analysis of airflow, structural mechanics and aerosol dynamics in a four-generation acinar model
P Li, W Guo, J Fan, C Su, X Zhao, X Xu - Journal of Aerosol Science, 2023 - Elsevier
Elucidating the aerosol dynamics in the pulmonary acinar region is imperative for both
health risk assessment and inhalation therapy, especially nowadays with the occurrence of …
health risk assessment and inhalation therapy, especially nowadays with the occurrence of …
Alveolar size effects on nanoparticle deposition in rhythmically expanding-contracting terminal alveolar models
Significant differences in alveolar size exist in humans of different ages, gender, health, and
among different species. The effects of alveolar sizes, as well as the accompanying …
among different species. The effects of alveolar sizes, as well as the accompanying …