Nanotherapeutics for pulmonary drug delivery: An emerging approach to overcome respiratory diseases

E Kole, K Jadhav, N Shirsath, P Dudhe… - Journal of drug delivery …, 2023 - Elsevier
Pulmonary diseases pose an immense threat to global health. Several nanotherapeutics-
based approaches aimed to tackle pulmonary ailments in recent years. The current …

Recent advances in the understanding of alveolar flow

J Dong, Y Yang, Y Zhu - Biomicrofluidics, 2022 - pubs.aip.org
Understanding the dynamics of airflow in alveoli and its effect on the behavior of particle
transport and deposition is important for understanding lung functions and the cause of …

[HTML][HTML] Nanoparticle transport and deposition in a heterogeneous human lung airway tree: An efficient one path model for CFD simulations

MM Rahman, M Zhao, MS Islam, K Dong… - European Journal of …, 2022 - Elsevier
Understanding nano-particle inhalation in human lung airways helps targeted drug delivery
for treating lung diseases. A wide range of numerical models have been developed to …

Towards whole-lung simulations of aerosol deposition: A model of the deep lung

PG Koullapis, FS Stylianou, J Sznitman, B Olsson… - Journal of Aerosol …, 2020 - Elsevier
In silico methods can be used to estimate regional deposition of inhaled aerosols in regions
of the lung that are inaccessible by direct measurements. Knowledge of deposited dose is …

[HTML][HTML] A critical analysis of the CFD-DEM simulation of pharmaceutical aerosols deposition in extra-thoracic airways

GH Spasov, R Rossi, A Vanossi, C Cottini… - International Journal of …, 2022 - Elsevier
Recent advances in the characterization of the human respiratory system and in multi-phase
flow dynamics in complex geometries have led numerical simulations to play an expanding …

[HTML][HTML] A numerical study of the aerosol behavior in intra-acinar region of a human lung

D Ciloglu - Physics of Fluids, 2020 - pubs.aip.org
The determination of the particle dynamics in the human acinar airways having millions of
alveoli is critical in preventing potential health problems and delivering therapeutic particles …

Inhalable spray-dried polycaprolactone-based microparticles of Sorafenib Tosylate with promising efficacy on A549 cells

KS Yadav, HC Raut, HP Nijhawan - … Development and Technology, 2023 - Taylor & Francis
The study developed and evaluated Sorafenib Tosylate (SRT)-loaded polymeric
microparticles (MPs) using biodegradable polymer polycaprolactone (PCL) as a potential …

VIVID: In Vivo End-to-End Molecular Communication Model for COVID-19

S Pal, N Islam, S Misra - IEEE Transactions on Molecular …, 2021 - ieeexplore.ieee.org
As an alternative to ongoing efforts for vaccine development, scientists are exploring novel
approaches to provide innovative therapeutics, such as nanoparticle-and stem cell-based …

Fluid-structure interaction analysis of airflow, structural mechanics and aerosol dynamics in a four-generation acinar model

P Li, W Guo, J Fan, C Su, X Zhao, X Xu - Journal of Aerosol Science, 2023 - Elsevier
Elucidating the aerosol dynamics in the pulmonary acinar region is imperative for both
health risk assessment and inhalation therapy, especially nowadays with the occurrence of …

Alveolar size effects on nanoparticle deposition in rhythmically expanding-contracting terminal alveolar models

J **, M Talaat, XA Si, P Han, H Dong… - Computers in biology and …, 2020 - Elsevier
Significant differences in alveolar size exist in humans of different ages, gender, health, and
among different species. The effects of alveolar sizes, as well as the accompanying …