Cyclin-dependent kinases (cdks) are critical regulators of cell cycle progression and RNA
transcription. A variety of genetic and epigenetic events cause universal overactivity of the …

Imidazo [1, 2-a] pyridine is a bicyclic system with a bridgehead nitrogen atom, of growing
interest in medicinal chemistry. The paper deals with the recent progress realised in the …

A pharmacological approach to inhibition of cyclin-dependent kinases 4 and 6 (Cdk4/6)
using highly selective small molecule inhibitors has the potential to provide novel cancer …

Cyclin-dependent kinase-2 (CDK2) is a member of protein kinase family. It plays an
important role in regulating various events of eukaryotic cell division cycle. Accumulated …

Lead optimization of a high‐throughput screening hit led to the rapid identification of
aminopyrimidine ZK 304709, a multitargeted CDK and VEGF‐R inhibitor that displayed a …

Inhibition of the cell cycle kinase, cyclin-dependent kinase-4 (Cdk4), is expected to provide
an effective method for the treatment of proliferative diseases such as cancer. The pyrido [2 …

Considering the fundamental role of protein kinases in the mechanism of protein
phosphorylation in critical cellular processes, their dysregulation, especially in cancers, has …

Imidazo [1, 2-a] pyridine has been shown to be an important biologically active moiety. This
review is a compilation of the scattered output of results of the anticancer activities of the …

The kinase PIM-1 plays a pivotal role in cytokine signaling and is implicated in the
development of a number of tumors. The three-dimensional structure of PIM-1 is …

This review surveys recent developments (reported in the last fifteen years) in
organometallic‐chemistry‐based methods for the functionalization of imidazo [1, 2‐a] …