The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked
widespread enthusiasm for the development of new models of human disease, enhanced …

Induced pluripotent stem cell (iPSC)-based disease modelling and the cell replacement
therapy approach have proven to be very powerful and instrumental in biomedical research …

Cancer is a complex disease in which both genetic defects and microenvironmental
components contribute to the development, progression, and metastasization of disease …

Osteosarcoma is a rare tumor diagnosed at any age; however younger age is a common risk
factor. In addition, multiple factors are believed to contribute to higher rates of osteosarcoma …

It is well established that human pluripotent stem cells (hPSCs) can acquire genetic and
epigenetic changes during culture in vitro. Given the increasing use of hPSCs in research …

Simple Summary Presently, the investigation of the tumor is carried out using different
models. One of the promising areas is the creation of 3D tumor models, such as spheroids …

Organoid technologies enable the creation of in vitro physiologic systems that model tissues
of origin more accurately than classical culture approaches. Seminal characteristics of these …

Aims Emerging evidence indicates that long non-coding RNAs (lncRNAs) play a vital role in
cardiovascular physiology and pathology. Although the lncRNA TUG1 is implicated in …

The imprinted oncofetal long non-coding RNA (lncRNA) H19 is expressed in the embryo,
down-regulated at birth and then reappears in tumors. Its role in tumor initiation and …

Abstract Aims The H19 lncRNA, a highly abundant and conserved imprinted gene, has been
implicated in many essential biological processes and diseases. However, the function of …