Using MetaboAnalyst 5.0 for LC–HRMS spectra processing, multi-omics integration and covariate adjustment of global metabolomics data

Z Pang, G Zhou, J Ewald, L Chang, O Hacariz… - Nature protocols, 2022 - nature.com
Liquid chromatography coupled with high-resolution mass spectrometry (LC–HRMS) has
become a workhorse in global metabolomics studies with growing applications across …

Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices

S Alseekh, A Aharoni, Y Brotman, K Contrepois… - Nature …, 2021 - nature.com
Mass spectrometry-based metabolomics approaches can enable detection and
quantification of many thousands of metabolite features simultaneously. However …

Metabolomics-centered mining of plant metabolic diversity and function: Past decade and future perspectives

S Shen, C Zhan, C Yang, AR Fernie, J Luo - Molecular Plant, 2023 - cell.com
Plants are natural experts in organic synthesis, being able to generate large numbers of
specific metabolites with widely varying structures that help them adapt to variable survival …

Recent advances in the application of metabolomics for food safety control and food quality analyses

S Li, Y Tian, P Jiang, Y Lin, X Liu… - Critical reviews in food …, 2021 - Taylor & Francis
As one of the omics fields, metabolomics has unique advantages in facilitating the
understanding of physiological and pathological activities in biology, physiology, pathology …

[HTML][HTML] MapMan4: a refined protein classification and annotation framework applicable to multi-omics data analysis

R Schwacke, GY Ponce-Soto, K Krause, AM Bolger… - Molecular plant, 2019 - cell.com
Genome sequences from over 200 plant species have already been published, with this
number expected to increase rapidly due to advances in sequencing technologies. Once a …

The structure and function of major plant metabolite modifications

S Wang, S Alseekh, AR Fernie, J Luo - Molecular Plant, 2019 - cell.com
Plants produce a myriad of structurally and functionally diverse metabolites that play many
different roles in plant growth and development and in plant response to continually …

Metabolomics in the context of plant natural products research: From sample preparation to metabolite analysis

MA Salem, L Perez de Souza, A Serag, AR Fernie… - Metabolites, 2020 - mdpi.com
Plant-derived natural products have long been considered a valuable source of lead
compounds for drug development. Natural extracts are usually composed of hundreds to …

Exploring the diversity of plant metabolism

C Fang, AR Fernie, J Luo - Trends in Plant Science, 2019 - cell.com
Plants produce a huge array of metabolites, far more than those produced by most other
organisms. Unraveling this diversity and its underlying genetic variation has attracted …

[HTML][HTML] The style and substance of plant flavonoid decoration; towards defining both structure and function

S Alseekh, LP de Souza, M Benina, AR Fernie - Phytochemistry, 2020 - Elsevier
Over 8000 different flavonoids have been described and a considerable number of new
flavonoid structures are being elucidated every year. The advent of metabolomics alongside …

Metabolomics: a systems biology approach for enhancing heat stress tolerance in plants

A Raza - Plant cell reports, 2022 - Springer
Key message Comprehensive metabolomic investigations provide a large set of stress-
related metabolites and metabolic pathways, advancing crops under heat stress conditions …