Expansions of simple tandem repeats are responsible for almost 50 human diseases, the
majority of which are severe, degenerative, and not currently treatable or preventable. In this …

Astrocytes comprise half of the cells in the brain. Although astrocytes have traditionally been
described as playing a supportive role for neurons, they have recently been recognized as …

The expansion of repeated sequences is the cause of over 30 inherited genetic diseases,
including Huntington disease, myotonic dystrophy (types 1 and 2), fragile X syndrome, many …

Recently, inspired by the similar clinical and pathological features shared with fragile X-
associated tremor/ataxia syndrome (FXTAS), abnormal expansion of CGG repeats in the …

Genomic DNA replicates according to a defined temporal program in which early-replicating
loci are associated with open chromatin, higher gene density, and increased gene …

Abstract The Repeat Expansion Diseases (REDs) are a large group of human genetic
disorders that result from an increase in the number of repeats in a disease-specific tandem …

Background Eukaryotic genome duplication starts at discrete sequences (replication origins)
that coordinate cell cycle progression, ensure genomic stability and modulate gene …

Expanded tandem repeat DNAs are associated with various unusual chromosomal lesions,
despiralizations, multi-branched inter-chromosomal associations, and fragile sites. Fragile …

Trinucleotide repeats are a particular class of microsatellites whose large expansions are
responsible for at least two dozen human neurological and developmental disorders …

The human genome has many chromosomal regions that are fragile, demonstrating
chromatin breaks, gaps, or constrictions on exposure to replication stress. Common fragile …