Clinical metagenomic next-generation sequencing (mNGS), the comprehensive analysis of
microbial and host genetic material (DNA and RNA) in samples from patients, is rapidly …

Background Metagenomic next-generation sequencing (mNGS) for pathogen detection is
becoming increasingly available as a method to identify pathogens in cases of suspected …

Background Metagenomic next-generation sequencing (mNGS) has enabled the rapid,
unbiased detection and identification of microbes without pathogen-specific reagents …

The application of sequencing technology is shifting from research to clinical laboratories
owing to rapid technological developments and substantially reduced costs. However …

Background Metagenomic next-generation sequencing (mNGS) has changed the diagnosis
landscape of lower respiratory tract infections (LRIs). With the development of newer …

Over the past two decades, the diagnosis rate for patients with encephalitis has remained
poor despite advances in pathogen-specific testing such as PCR and antigen assays …

Objectives: To evaluate the potential of metagenomic next-generation sequencing (mNGS),
compared with that of comprehensive conventional microbiological tests (CMTs), of …

Lower respiratory tract infections are associated with high morbidity and mortality and
significant clinical harm. Due to the limited ability of traditional pathogen detection methods …

The purpose of this study was to assess the value of metagenomic next-generation
sequencing (mNGS) of bronchoalveolar lavage fluid (BALF) for the diagnosis of severe …

Understanding the regional pathogen landscape and surveillance of emerging pathogens is
key to mitigating epidemics. Challenges lie in resource-scarce settings, where outbreaks are …