Metabolomics and isotope tracing
Great strides have been made over the past decade toward comprehensive study of
metabolism. Mass spectrometry (MS) has played a central role by enabling measurement of …
metabolism. Mass spectrometry (MS) has played a central role by enabling measurement of …
Consensus guidelines for the use and interpretation of angiogenesis assays
The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …
important roles in growth and development, tissue and organ regeneration, as well as …
[HTML][HTML] Omics-driven systems interrogation of metabolic dysregulation in COVID-19 pathogenesis
Summary The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented
threat to global public health. Herein, we utilized a combination of targeted and untargeted …
threat to global public health. Herein, we utilized a combination of targeted and untargeted …
An inhibitor of oxidative phosphorylation exploits cancer vulnerability
Metabolic reprograming is an emerging hallmark of tumor biology and an actively pursued
opportunity in discovery of oncology drugs. Extensive efforts have focused on therapeutic …
opportunity in discovery of oncology drugs. Extensive efforts have focused on therapeutic …
Cardioprotection and lifespan extension by the natural polyamine spermidine
Aging is associated with an increased risk of cardiovascular disease and death. Here we
show that oral supplementation of the natural polyamine spermidine extends the lifespan of …
show that oral supplementation of the natural polyamine spermidine extends the lifespan of …
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
Cancer cells have metabolic dependencies that distinguish them from their normal
counterparts. Among these dependencies is an increased use of the amino acid glutamine …
counterparts. Among these dependencies is an increased use of the amino acid glutamine …
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease characterized by an
intense fibrotic stromal response and deregulated metabolism,,,. The role of the stroma in …
intense fibrotic stromal response and deregulated metabolism,,,. The role of the stroma in …
PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
VS LeBleu, JT O'Connell, KN Gonzalez Herrera… - Nature cell …, 2014 - nature.com
Cancer cells can divert metabolites into anabolic pathways to support their rapid
proliferation and to accumulate the cellular building blocks required for tumour growth …
proliferation and to accumulate the cellular building blocks required for tumour growth …
[HTML][HTML] Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
Tumor maintenance relies on continued activity of driver oncogenes, although their rate-
limiting role is highly context dependent. Oncogenic Kras mutation is the signature event in …
limiting role is highly context dependent. Oncogenic Kras mutation is the signature event in …
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers in western
countries, with a median survival of 6 months and an extremely low percentage of long-term …
countries, with a median survival of 6 months and an extremely low percentage of long-term …