Aging is accompanied by alterations in the body with time-related to decline of physiological
integrity and functionality process, responsible for increasing diseases and vulnerability to …

Impaired mitochondrial function and abnormalities in the tryptophan (Trp)-kynurenine (Kyn)
pathway are linked to age-related mood disorders. This study investigated the effect of …

The NLRP3-mediated pyroptosis, which could affect inflammation response, plays a key role
in the development of depression. Acupuncture has been shown to be an effective treatment …

Chronic stress is known to perturb serotonergic regulation in the brain, leading to mood,
learning and memory impairments and increasing the risk of develo** mood disorders …

Major depressive disorder (MDD) is considered a psychiatric disorder and have a
relationship with stressful events. Although the common therapeutic approaches against …

This study aimed to determine the effects of mitotherapy on learning and memory and
hippocampal kynurenine (Kyn) pathway, mitochondria function, and dendritic arborization …

Background Several clinical neuroimaging studies have reported structural and functional
brain abnormalities associated with peripheral inflammatory cytokines or kynurenine …

Structural and functional recovery from stress-induced depression is impaired in the context
of aging brain. Since investigating the molecular substrates that facilitate behavioral …

Objective (s): Apoptosis is common and often comorbid with aging and stress-related mood
disorders. Evidence suggests that fresh mitochondria could reverse age-related …

Along with altering brain responses to stress, aging may also impair recovery from
depression symptoms. In the present study, we investigated depressive-like behaviors in …