1, 3, 4-Thiadiazole: synthesis, reactions, and applications in medicinal, agricultural, and materials chemistry

Y Hu, CY Li, XM Wang, YH Yang, HL Zhu - Chemical reviews, 2014 - ACS Publications
Over the past decades, the bulk of chemists' interests have been on heterocyclic compounds
and their various derivatives as well as their applications in the pharmaceutical and …

Novel 1, 2, 4-oxadiazole derivatives in drug discovery

K Biernacki, M Daśko, O Ciupak, K Kubiński, J Rachon… - Pharmaceuticals, 2020 - mdpi.com
Five-membered 1, 2, 4-oxadiazole heterocyclic ring has received considerable attention
because of its unique bioisosteric properties and an unusually wide spectrum of biological …

Synthetic approaches and pharmacological activity of 1, 3, 4-oxadiazoles: a review of the literature from 2000–2012

CS De Oliveira, BF Lira, JM Barbosa-Filho… - Molecules, 2012 - mdpi.com
Molecules | Free Full-Text | Synthetic Approaches and Pharmacological Activity of 1,3,4-Oxadiazoles:
A Review of the Literature from 2000–2012 Next Article in Journal Chemical Composition of …

Current scenario of tetrazole hybrids for antibacterial activity

F Gao, J **ao, G Huang - European journal of medicinal chemistry, 2019 - Elsevier
The incidence of invasive bacterial infections has increased remarkably over the past two
decades, which was mainly attributed to the increasing emergence of drug-resistant bacteria …

Synthesis of 2-Amino-1,3,4-oxadiazoles and 2-Amino-1,3,4-thiadiazoles via Sequential Condensation and I2-Mediated Oxidative C–O/C–S Bond Formation

P Niu, J Kang, X Tian, L Song, H Liu, J Wu… - The Journal of …, 2015 - ACS Publications
2-Amino-substituted 1, 3, 4-oxadiazoles and 1, 3, 4-thiadiazoles were synthesized via
condensation of semicarbazide/thiosemicarbazide and the corresponding aldehydes …

A review exploring therapeutic worth of 1, 3, 4-oxadiazole tailored compounds

G Verma, MF Khan, W Akhtar, MM Alam… - Mini Reviews in …, 2019 - ingentaconnect.com
1, 3, 4-Oxadiazole, a five-membered aromatic ring can be seen in a number of synthetic
molecules. The peculiar structural feature of 1, 3, 4-oxadiazole ring with pyridine type of …

I2-Mediated Oxidative C–O Bond Formation for the Synthesis of 1,3,4-Oxadiazoles from Aldehydes and Hydrazides

W Yu, G Huang, Y Zhang, H Liu, L Dong… - The Journal of …, 2013 - ACS Publications
A practical and transition-metal-free oxidative cyclization of acylhydrazones into 1, 3, 4-
oxadiazoles has been developed by employing stoichiometric molecular iodine in the …

Novel chalcone derivatives containing a 1, 2, 4-triazine moiety: design, synthesis, antibacterial and antiviral activities

X Tang, S Su, M Chen, J He, R **a, T Guo, Y Chen… - RSC …, 2019 - pubs.rsc.org
A series of novel chalcone derivatives containing the 1, 2, 4-triazine moiety were
synthesized and their structures were confirmed by 1H NMR, 13C NMR and elemental …

New oxadiazole bearing thiosemicarbazide analogues: Synthesis, anti-alzheimer inhibitory potential and their molecular docking study

H Ullah, F Fayyaz, A Hussain, F Rahim, S Hayat… - Chemical Data …, 2022 - Elsevier
Synthesized oxadiazole-bearing thiosemicarbazide analogues (1–14) were characterized
by NMR and HR-EIMS and were tested against acetylcholinesterase and …

General α‐amino 1, 3, 4‐oxadiazole synthesis via late‐stage reductive functionalization of tertiary amides and lactams

D Matheau‐Raven, DJ Dixon - … Chemie International Edition, 2021 - Wiley Online Library
An iridium‐catalyzed reductive three‐component coupling reaction for the synthesis of
medicinally relevant α‐amino 1, 3, 4‐oxadiazoles from abundant tertiary amides or lactams …