Sp1 and the 'hallmarks of cancer'
K Beishline, J Azizkhan‐Clifford - The FEBS journal, 2015 - Wiley Online Library
For many years, transcription factor Sp1 was viewed as a basal transcription factor and
relegated to a role in the regulation of so‐called housekee** genes. Identification of Sp1's …
relegated to a role in the regulation of so‐called housekee** genes. Identification of Sp1's …
Sp1 transcription factor: A long-standing target in cancer chemotherapy
Abstract Sp1 (specificity protein 1) is a well-known member of a family of transcription factors
that also includes Sp2, Sp3 and Sp4, which are implicated in an ample variety of essential …
that also includes Sp2, Sp3 and Sp4, which are implicated in an ample variety of essential …
Human fetal microglia acquire homeostatic immune-sensing properties early in development
Microglia, immune cells of the central nervous system (CNS), are important for tissue
development and maintenance and are implicated in CNS disease, but we lack …
development and maintenance and are implicated in CNS disease, but we lack …
DNA hypermethylation in tumorigenesis: epigenetics joins genetics
Recently, the concept that epigenetic, as well as genetic, events might be central to the
evolution of human cancer is re-emerging. Cancers often exhibit an aberrant methylation of …
evolution of human cancer is re-emerging. Cancers often exhibit an aberrant methylation of …
Sp1-and Krüppel-like transcription factors
Sp1-like proteins and Krüppel-like factors (KLFs) are highly related zinc-finger proteins that
are important components of the eukaryotic cellular transcriptional machinery. By regulating …
are important components of the eukaryotic cellular transcriptional machinery. By regulating …
A protein interaction network for pluripotency of embryonic stem cells
Embryonic stem (ES) cells are pluripotent, and of therapeutic potential in regenerative
medicine,. Understanding pluripotency at the molecular level should illuminate fundamental …
medicine,. Understanding pluripotency at the molecular level should illuminate fundamental …
Sp1 and krüppel‐like factor family of transcription factors in cell growth regulation and cancer
AR Black, JD Black… - Journal of cellular …, 2001 - Wiley Online Library
The Sp/KLF family contains at least twenty identi® ed members which include Sp1-4 and
numerous kruÈppel-like factors. Members of the family bind with varying af® nities to …
numerous kruÈppel-like factors. Members of the family bind with varying af® nities to …
The Sp-family of transcription factors
G Suske - Gene, 1999 - Elsevier
GC-boxes and related motifs are frequently occurring DNA-elements present in many
promoters and enhancers. In contrast to other elements it was generally thought that the …
promoters and enhancers. In contrast to other elements it was generally thought that the …
Nuclear activators and coactivators in mammalian mitochondrial biogenesis
RC Scarpulla - Biochimica et biophysica acta (BBA)-gene structure …, 2002 - Elsevier
The biogenesis of mitochondria requires the expression of a large number of genes, most of
which reside in the nuclear genome. The protein-coding capacity of mtDNA is limited to 13 …
which reside in the nuclear genome. The protein-coding capacity of mtDNA is limited to 13 …
Inference of cell type-specific gene regulatory networks on cell lineages from single cell omic datasets
Cell type-specific gene expression patterns are outputs of transcriptional gene regulatory
networks (GRNs) that connect transcription factors and signaling proteins to target genes …
networks (GRNs) that connect transcription factors and signaling proteins to target genes …