As the most dominant cell type in the skin, keratinocytes play critical roles in wound repair
not only as structural cells but also exerting important immune functions. This review focuses …

The skin is a complex organ that has devised numerous strategies, such as physical,
chemical, and microbiological barriers, to protect the host from external insults. In addition …

The skin serves as the primary interface between our body and the external environment
and acts as a barrier against entry of physical agents, chemicals, and microbes …

The ability to rapidly restore the integrity of a broken skin barrier is critical and is the ultimate
goal of therapies for hard-to-heal-ulcers. Unfortunately effective treatments to enhance …

In past 10 years, microRNAs (miRNAs) have gained scientific attention due to their
importance in the pathophysiology of allergic diseases and their potential as biomarkers in …

Significance: This review article provides an overview of the critical roles of the innate
immune system to wound healing. It explores aspects of dysregulation of individual innate …

As the key defense molecules originally identified in Drosophila, Toll‐like receptor (TLR)
superfamily members play a fundamental role in detecting invading pathogens or damage …

The pathogenesis of osteoarthritis (OA) is poorly understood, and therapeutic approaches
are limited to preventing progression of the disease. Recent studies have shown that …

Wound healing is a complex process that is characterized by an initial inflammatory phase
followed by a proliferative phase. This transition is a critical regulatory point; however, the …

Innate immune responses are primary, relatively limited, and specific responses to
numerous pathogens and toxic molecules. Protein expression involved in these innate …