The multifaceted roles of fatty acid synthesis in cancer

F Röhrig, A Schulze - Nature reviews cancer, 2016 - nature.com
Lipid metabolism, in particular the synthesis of fatty acids (FAs), is an essential cellular
process that converts nutrients into metabolic intermediates for membrane biosynthesis …

[HTML][HTML] Fatty acids and evolving roles of their proteins in neurological, cardiovascular disorders and cancers

R Mallick, S Basak, AK Duttaroy - Progress in lipid research, 2021 - Elsevier
The dysregulation of fat metabolism is involved in various disorders, including
neurodegenerative, cardiovascular, and cancers. The uptake of long-chain fatty acids …

Single-cell analysis reveals altered tumor microenvironments of relapse-and remission-associated pediatric acute myeloid leukemia

H Mumme, BE Thomas, SS Bhasin, U Krishnan… - Nature …, 2023 - nature.com
Acute myeloid leukemia (AML) microenvironment exhibits cellular and molecular differences
among various subtypes. Here, we utilize single-cell RNA sequencing (scRNA-seq) to …

FABP5 promotes lymph node metastasis in cervical cancer by reprogramming fatty acid metabolism

C Zhang, Y Liao, P Liu, Q Du, Y Liang, S Ooi… - …, 2020 - pmc.ncbi.nlm.nih.gov
Patients with cervical cancer (CCa) with lymph node metastasis (LNM) have an extremely
poor prognosis. Elucidation of the molecular mechanisms underlying LNM may provide …

Diverse roles of fatty acid binding proteins (FABPs) in development and pathogenesis of cancers

M Amiri, S Yousefnia, FS Forootan, M Peymani… - Gene, 2018 - Elsevier
One of the most importantly involved pathways in cancer development is fatty-acid signaling
pathway. Synthesized lipids as energetic sources are consumed by cancer cells for …

Role of fatty acid binding proteins (FABPs) in cancer development and progression

IH McKillop, CA Girardi, KJ Thompson - Cellular signalling, 2019 - Elsevier
Fatty acid binding proteins (FABPs) are small, water soluble proteins that bind long chain
fatty acids and other biologically active ligands to facilitate intracellular localization. Twelve …

Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-κB) signaling in …

S Senga, N Kobayashi, K Kawaguchi, A Ando… - Biochimica et Biophysica …, 2018 - Elsevier
Fatty acid-binding proteins (FABPs) are involved in binding and storing hydrophobic ligands
such as long-chain fatty acids, as well as transporting them to the appropriate compartments …

The influence of peroxisome proliferator-activated receptor γ (PPARγ) ligands on cancer cell tumorigenicity

S Yousefnia, S Momenzadeh, FS Forootan, K Ghaedi… - Gene, 2018 - Elsevier
Peroxisome proliferator-activated receptor γ (PPARγ) belongs to the nuclear receptor
superfamily of PPARs (PPARα, PPARβ/δ, PPARγ). Numerous studies have concentrated on …

Modulation of the endocannabinoid system as a potential anticancer strategy

R Ramer, R Schwarz, B Hinz - Frontiers in pharmacology, 2019 - frontiersin.org
Currently, the involvement of the endocannabinoid system in cancer development and
possible options for a cancer-regressive effect of cannabinoids are controversially …

PFAS and potential adverse effects on bone and adipose tissue through interactions with PPARγ

AB Kirk, S Michelsen-Correa, C Rosen… - …, 2021 - academic.oup.com
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a widely dispersed, broad class of
synthetic chemicals with diverse biological effects, including effects on adipose and bone …