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The multifaceted roles of fatty acid synthesis in cancer
F Röhrig, A Schulze - Nature reviews cancer, 2016 - nature.com
Lipid metabolism, in particular the synthesis of fatty acids (FAs), is an essential cellular
process that converts nutrients into metabolic intermediates for membrane biosynthesis …
process that converts nutrients into metabolic intermediates for membrane biosynthesis …
[HTML][HTML] Fatty acids and evolving roles of their proteins in neurological, cardiovascular disorders and cancers
The dysregulation of fat metabolism is involved in various disorders, including
neurodegenerative, cardiovascular, and cancers. The uptake of long-chain fatty acids …
neurodegenerative, cardiovascular, and cancers. The uptake of long-chain fatty acids …
Single-cell analysis reveals altered tumor microenvironments of relapse-and remission-associated pediatric acute myeloid leukemia
Acute myeloid leukemia (AML) microenvironment exhibits cellular and molecular differences
among various subtypes. Here, we utilize single-cell RNA sequencing (scRNA-seq) to …
among various subtypes. Here, we utilize single-cell RNA sequencing (scRNA-seq) to …
FABP5 promotes lymph node metastasis in cervical cancer by reprogramming fatty acid metabolism
C Zhang, Y Liao, P Liu, Q Du, Y Liang, S Ooi… - …, 2020 - pmc.ncbi.nlm.nih.gov
Patients with cervical cancer (CCa) with lymph node metastasis (LNM) have an extremely
poor prognosis. Elucidation of the molecular mechanisms underlying LNM may provide …
poor prognosis. Elucidation of the molecular mechanisms underlying LNM may provide …
Diverse roles of fatty acid binding proteins (FABPs) in development and pathogenesis of cancers
One of the most importantly involved pathways in cancer development is fatty-acid signaling
pathway. Synthesized lipids as energetic sources are consumed by cancer cells for …
pathway. Synthesized lipids as energetic sources are consumed by cancer cells for …
Role of fatty acid binding proteins (FABPs) in cancer development and progression
Fatty acid binding proteins (FABPs) are small, water soluble proteins that bind long chain
fatty acids and other biologically active ligands to facilitate intracellular localization. Twelve …
fatty acids and other biologically active ligands to facilitate intracellular localization. Twelve …
Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-κB) signaling in …
S Senga, N Kobayashi, K Kawaguchi, A Ando… - Biochimica et Biophysica …, 2018 - Elsevier
Fatty acid-binding proteins (FABPs) are involved in binding and storing hydrophobic ligands
such as long-chain fatty acids, as well as transporting them to the appropriate compartments …
such as long-chain fatty acids, as well as transporting them to the appropriate compartments …
The influence of peroxisome proliferator-activated receptor γ (PPARγ) ligands on cancer cell tumorigenicity
Peroxisome proliferator-activated receptor γ (PPARγ) belongs to the nuclear receptor
superfamily of PPARs (PPARα, PPARβ/δ, PPARγ). Numerous studies have concentrated on …
superfamily of PPARs (PPARα, PPARβ/δ, PPARγ). Numerous studies have concentrated on …
Modulation of the endocannabinoid system as a potential anticancer strategy
R Ramer, R Schwarz, B Hinz - Frontiers in pharmacology, 2019 - frontiersin.org
Currently, the involvement of the endocannabinoid system in cancer development and
possible options for a cancer-regressive effect of cannabinoids are controversially …
possible options for a cancer-regressive effect of cannabinoids are controversially …
PFAS and potential adverse effects on bone and adipose tissue through interactions with PPARγ
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a widely dispersed, broad class of
synthetic chemicals with diverse biological effects, including effects on adipose and bone …
synthetic chemicals with diverse biological effects, including effects on adipose and bone …