Post-traumatic stress disorder (PTSD), characterized by abnormally persistent and
distressing memories, is a chronic debilitating condition in need of new treatment options …

The basolateral amygdala (BLA) is reliably activated by psychological stress and
hyperactive in conditions of pathological stress or trauma; however, subsets of BLA neurons …

Glucocorticoids are potent memory modulators that can modify behavior in an adaptive or
maladaptive manner. Elevated glucocorticoid levels after learning promote memory …

The overconsumption of sugar-sweetened food and beverages underpins the current rise in
obesity rates. Sugar overconsumption induces maladaptive neuroplasticity to decrease …

This study establishes mirdametinib as the first MEK inhibitor that can undergo clinical
development for psychiatric indications such as post-traumatic stress disorder (PTSD). PTSD …

Post-traumatic stress disorder (PTSD) is a psychiatric disorder that afflicts many individuals.
However, its molecular and cellular mechanisms remain largely unexplored. Here, we found …

La hipótesis del marcador somático (SMH) ha sido una de las teorías más influyentes en las
neurociencias desde principios de los años 90s en que fue formulada por Antonio Damasio …

Regulated fear and extinction memory is essential for balanced behavioral response. Limbic
brain regions are susceptible to hypobaric hypoxia (HH) and are putative target for fear …

Post-traumatic stress disorder (PTSD) is a debilitating and chronic fear-based disorder.
Pavlovian fear conditioning protocols have long been utilised to manipulate and study these …

Systems consolidation (SC) theory proposes that recent, contextually rich memories are
stored in the hippocampus (HPC). As these memories become remote, they are believed to …