Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Growth differentiation factor 15 (GDF15) is a cytokine best known for affecting systemic
energy metabolism through its anorectic action. GDF15 expression and secretion from …

Caloric restriction that promotes weight loss is an effective strategy for treating non-alcoholic
fatty liver disease and improving insulin sensitivity in people with type 2 diabetes. Despite its …

In addition to its canonical function of protection from pathogens, the immune system can
also alter behaviour,. The scope and mechanisms of behavioural modifications by the …

The advent of proteomics offers an unprecedented opportunity to predict dementia onset.
We examined this in data from 52,645 adults without dementia in the UK Biobank, with 1,417 …

Summary Growth differentiation factor 15 (GDF15) induces weight loss and increases insulin
action in obese rodents. Whether and how GDF15 improves insulin action without weight …

Abstract Growth differentiation factor 15 (GDF15) is recently emerging not only as a stress-
related mitokine, but also as a key player in the aging process, being one of the most up …

Effective therapies capable of simultaneously inhibiting inflammation and promoting bone
healing remain to be developed for inflammatory bone disease. Stem cell therapies hold …

Fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (GDF15) are
established as stress-responsive cytokines that can modulate energy balance by increasing …

Mitochondrial dysfunction and oxidative stress-mediated inflammasome activation play
critical roles in the pathogenesis of the non-alcoholic fatty liver disease (NAFLD). Non …