Over the past decade, the emergence of effective immunotherapies has revolutionized the
clinical management of many types of cancers. However, long-term durable tumour control …

Extracellular vesicles (EVs) function as a mode of intercellular communication and
molecular transfer to elicit diverse biological/functional response. Accumulating evidence …

Combining RNA sequencing, ribosome profiling, and mass spectrometry, we elucidate the
contribution of non-canonical translation to the proteome and major histocompatibility …

Background The human leucocyte antigen (HLA) complex controls adaptive immunity by
presenting defined fractions of the intracellular and extracellular protein content to immune …

Abstract The SysteMHC Atlas v1. 0 was the first public repository dedicated to mass
spectrometry-based immunopeptidomics. Here we introduce a newly released version of the …

Simple Summary A new class of drugs, termed Immune Checkpoint Inhibitors, has
revolutionized cancer therapy during the last few years. Unfortunately, these drugs are only …

The identification of tumor-specific antigens (TSAs) is critical for develo** effective cancer
immunotherapies. Mass spectrometry (MS)-based immunopeptidomics has emerged as a …

The identification of major histocompatibility complex (MHC)‐binding peptides in mass
spectrometry (MS)‐based immunopeptideomics relies largely on database search engines …

Simple Summary Cancer immunology is a rapidly evolving field. In this context, this review
article has three objectives. First, to explain the genomic origin of tumor antigens and to …

The immunopeptidome is the repertoire of peptides bound and presented by the MHC class
I, class II, and non-classical molecules. The peptides are produced by the degradation of …