The development of SARS-CoV-2 variants: the gene makes the disease
A novel coronavirus (SARS-CoV-2) emerged towards the end of 2019 that caused a severe
respiratory disease in humans called COVID-19. It led to a pandemic with a high rate of …
respiratory disease in humans called COVID-19. It led to a pandemic with a high rate of …
SARS-CoV-2 and emerging variants: unmasking structure, function, infection, and immune escape mechanisms
J Li, H Jia, M Tian, N Wu, X Yang, J Qi… - Frontiers in Cellular …, 2022 - frontiersin.org
As of April 1, 2022, over 468 million COVID-19 cases and over 6 million deaths have been
confirmed globally. Unlike the common coronavirus, SARS-CoV-2 has highly contagious …
confirmed globally. Unlike the common coronavirus, SARS-CoV-2 has highly contagious …
Low-Density Lipoprotein Receptor (LDLR) is involved in internalization of lentiviral particles pseudotyped with SARS-CoV-2 spike protein in ocular cells
Here, we present evidence that caveolae-mediated endocytosis using LDLR is the pathway
for SARS-CoV-2 virus internalization in the ocular cell line ARPE-19. Firstly, we found that …
for SARS-CoV-2 virus internalization in the ocular cell line ARPE-19. Firstly, we found that …
A synthetic biology approach for vaccine candidate design against delta strain of SARS-CoV-2 revealed disruption of favored codon pair as a better strategy over …
The SARS-CoV-2 delta variant (B. 1.617. 2) appeared for the first time in December 2020
and later spread worldwide. Currently available vaccines are not so efficacious in curbing …
and later spread worldwide. Currently available vaccines are not so efficacious in curbing …
The 29-nucleotide deletion in SARS-CoV: truncated versions of ORF8 are under purifying selection
Background Accessory proteins have diverse roles in coronavirus pathobiology. One of
them in SARS-CoV (the causative agent of the severe acute respiratory syndrome outbreak …
them in SARS-CoV (the causative agent of the severe acute respiratory syndrome outbreak …
Properties and Mechanisms of Deletions, Insertions, and Substitutions in the Evolutionary History of SARS-CoV-2
SARS-CoV-2 has accumulated many mutations since its emergence in late 2019.
Nucleotide substitutions leading to amino acid replacements constitute the primary material …
Nucleotide substitutions leading to amino acid replacements constitute the primary material …
Deletions across the SARS-CoV-2 genome: molecular mechanisms and putative functional consequences of deletions in accessory genes
The analysis of deletions may reveal evolutionary trends and provide new insight into the
surprising variability and rapidly spreading capability that SARS-CoV-2 has shown since its …
surprising variability and rapidly spreading capability that SARS-CoV-2 has shown since its …
Genomic analysis of SARS-CoV-2 alpha, beta and delta variants of concern uncovers signatures of neutral and non-neutral evolution
Due to the emergence of new variants of the SARS-CoV-2 coronavirus, the question of how
the viral genomes evolved, leading to the formation of highly infectious strains, becomes …
the viral genomes evolved, leading to the formation of highly infectious strains, becomes …
Genomic and Temporal Analysis of Deletions Correlated to qRT-PCR Dropout in N Gene in Alpha, Delta and Omicron Variants
G Gatti, M Brandolini, A Mancini, F Taddei, S Zannoli… - Viruses, 2023 - mdpi.com
Since the first SARS-CoV-2 outbreak, mutations such as single nucleotide polymorphisms
(SNPs) and insertion/deletions (INDELs) have changed and characterized the viral genome …
(SNPs) and insertion/deletions (INDELs) have changed and characterized the viral genome …
The frequency of defective genomes in Omicron differs from that of the Alpha, Beta and Delta variants
Abstract The SARS-CoV-2 Omicron variant emerged showing higher transmissibility and
possibly higher resistance to current COVID-19 vaccines than other variants dominating the …
possibly higher resistance to current COVID-19 vaccines than other variants dominating the …