The search for novel anticancer agents with more selectivity and lower toxicity continues to
be an area of intensive investigation. The unique structural features of spirooxindoles …

There is compelling evidence that incorporating a heterocyclic moiety into a steroid can alter
its pharmacological and pharmacokinetic properties, driving intense interest in the synthesis …

A series of steroidal hybrids with different terminal bioactive scaffolds were synthesized
using the molecular hybridization approach and further evaluated for their antiproliferative …

Starting from natural steroids (diosgenin, hecogenin, smilagenin, estrone), we have
prepared a wide panel of selenoderivatives, including benzoselenazolones …

Abstract A series of 5, 6-diaryl-1, 2, 4-triazines hybrids bearing a 1, 2, 3-triazole linker were
synthesized by molecular hybridization strategy and evaluated for antiproliferative activity …

Bulky tri‐isopropyl silyl (TIPS) substituents and deuterium atoms in the ligand design have
been shown to enhance the site‐selective oxidation of aliphatic C− H bonds and the …

A series of new steroidal pyridines have been synthesized through the based-promoted
three-component reaction and preliminarily evaluated for their antiproliferative activity …

Two series of novel steroidal spiro-pyrrolidinyl oxindoles 3a–t and 6a–c were designed and
synthesized from dehydroepiandrosterone using the 1, 3-dipolar cycloaddition as the key …

Steroid and its derivatives have been proved to have important and diverse biological
functions, which present the wide spectrum of biological activities such as antitumor …

Cancer cells always have increased ROS levels, thus making them more vulnerable to
persistent endogenous oxidative stress. The biochemical difference between cancer and …