Defining physiological normoxia for improved translation of cell physiology to animal models and humans
TP Keeley, GE Mann - Physiological reviews, 2019 - journals.physiology.org
The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …
Fluorine (19F) MRS and MRI in biomedicine
Shortly after the introduction of 1H MRI, fluorinated molecules were tested as MR‐detectable
tracers or contrast agents. Many fluorinated compounds, which are nontoxic and chemically …
tracers or contrast agents. Many fluorinated compounds, which are nontoxic and chemically …
MRI of the tumor microenvironment
The microenvironment within tumors is significantly different from that in normal tissues. A
major difference is seen in the chaotic vasculature of tumors, which results in unbalanced …
major difference is seen in the chaotic vasculature of tumors, which results in unbalanced …
In vivo imaging platform for tracking immunotherapeutic cells
Cellular therapeutics show great promise for the treatment of disease, but few noninvasive
techniques exist for monitoring the cells after administration. Here we present a magnetic …
techniques exist for monitoring the cells after administration. Here we present a magnetic …
Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions
Perfluorocarbon nanoemulsions can deliver lipophilic therapeutic agents to solid tumors and
simultaneously provide for monitoring nanocarrier biodistribution via ultrasonography and/or …
simultaneously provide for monitoring nanocarrier biodistribution via ultrasonography and/or …
Molecular imaging of hypoxia
Hypoxia, a condition of insufficient O 2 to support metabolism, occurs when the vascular
supply is interrupted, as in stroke or myocardial infarction, or when a tumor outgrows its …
supply is interrupted, as in stroke or myocardial infarction, or when a tumor outgrows its …
In vivo monitoring of inflammation after cardiac and cerebral ischemia by fluorine magnetic resonance imaging
Background—In this study, we developed and validated a new approach for in vivo
visualization of inflammatory processes by magnetic resonance imaging using …
visualization of inflammatory processes by magnetic resonance imaging using …
Nitroimidazoles and imaging hypoxia
A Nunn, K Linder, HW Strauss - European journal of nuclear medicine, 1995 - Springer
Decreased tissue oxygen tension is a component of many diseases. Although hypoxia can
be secondary to a low inspired P0 2 or a variety of lung disorders, the commonest cause is …
be secondary to a low inspired P0 2 or a variety of lung disorders, the commonest cause is …
19F magnetic resonance imaging for stem/progenitor cell tracking with multiple unique perfluorocarbon nanobeacons
KC Partlow, J Chen, JA Brant, AM Neubauer… - The FASEB …, 2007 - Wiley Online Library
ABSTRACT MRI has been employed to elucidate the migratory behavior of stem/progenitor
cells noninva‐sively in vivo with traditional proton (1H) imaging of iron oxide nanoparticle …
cells noninva‐sively in vivo with traditional proton (1H) imaging of iron oxide nanoparticle …
Fluorine-19 MRI for detection and quantification of immune cell therapy for cancer
Over the past two decades, immune cell therapy has emerged as a potent treatment for
multiple cancers, first through groundbreaking leukemia therapy, and more recently, by …
multiple cancers, first through groundbreaking leukemia therapy, and more recently, by …