Abstract The 2018 Nobel Prize in Physiology or Medicine was awarded to pioneers in the
field of cancer immunotherapy, as the utility of leveraging a patient's coordinated and …

Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying
development, disease, and regeneration. As organoid research expands, the need for clear …

The extracellular matrix (ECM) is a complex network with multiple functions, including
specific functions during tissue regeneration. Precisely, the properties of the ECM have been …

Much of our knowledge regarding the interactions between epithelial tissues and the
immune system has been gathered from animal models and co-cultures with cell lines …

Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy,
infection and transplantation, patient outcomes are linked to the degree of immune …

T cell senescence has been recognized to play an immunosuppressive role in the aging
population and cancer patients. Strategies dedicated to preventing or reversing replicative …

Bridging the gap between findings in preclinical 2D cell culture models and in vivo tissue
cultures has been challenging; the simple microenvironment of 2D monolayer culture …

Hematopoietic humanized (hu) mice are powerful tools for modeling the action of human
immune system and are widely used for preclinical studies and drug discovery. However …

Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune
response to cancer. Thus, induction of their activity is the ultimate aim of all …

T cell receptor-engineered T cell (TCR-T) therapy is free from the limit of surface antigen
expression of the target cells, which is a potential cellular immunotherapy for cancer …