Human disease models in drug development

A Loewa, JJ Feng, S Hedtrich - Nature reviews bioengineering, 2023 - nature.com
Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …

Nature-inspired micropatterns

Y Wang, G Zheng, N Jiang, G Ying, Y Li, X Cai… - Nature Reviews …, 2023 - nature.com
Micropatterned materials have developed in nature over 3.8 billion years, with remarkable
performance. Nature inspiration is the process of understanding biological mechanisms and …

Biomedical applications of microfluidic devices: a review

G Gharib, İ Bütün, Z Muganlı, G Kozalak, İ Namlı… - Biosensors, 2022 - mdpi.com
Both passive and active microfluidic chips are used in many biomedical and chemical
applications to support fluid mixing, particle manipulations, and signal detection. Passive …

Microfluidic organ-on-a-chip: a guide to biomaterial choice and fabrication

UMN Cao, Y Zhang, J Chen, D Sayson, S Pillai… - International journal of …, 2023 - mdpi.com
Organ-on-A-chip (OoAC) devices are miniaturized, functional, in vitro constructs that aim to
recapitulate the in vivo physiology of an organ using different cell types and extracellular …

Controlling the biodistribution and clearance of nanomedicines

H Cabral, J Li, K Miyata, K Kataoka - Nature Reviews Bioengineering, 2024 - nature.com
Nanomedicines improve drug bioavailability, the dose–response relationship, targeting
ability, efficacy and safety compared to conventional freely administered drugs …

Vat photopolymerization 3D printed microfluidic devices for organ-on-a-chip applications

LA Milton, MS Viglione, LJY Ong, GP Nordin, YC Toh - Lab on a Chip, 2023 - pubs.rsc.org
Organs-on-a-chip, or OoCs, are microfluidic tissue culture devices with micro-scaled
architectures that repeatedly achieve biomimicry of biological phenomena. They are well …

Intelligent biomaterialomics: molecular design, manufacturing, and biomedical applications

Y Yi, HW An, H Wang - Advanced Materials, 2024 - Wiley Online Library
Materialomics integrates experiment, theory, and computation in a high‐throughput manner,
and has changed the paradigm for the research and development of new functional …

Nose-on-chip nanobiosensors for early detection of lung cancer breath biomarkers

V Chaudhary, BA Taha, Lucky, S Rustagi, A Khosla… - ACS …, 2024 - ACS Publications
Lung cancer remains a global health concern, demanding the development of noninvasive,
prompt, selective, and point-of-care diagnostic tools. Correspondingly, breath analysis using …

Clam** strategies for organ-on-a-chip devices

DJ Teixeira Carvalho, L Moroni… - Nature Reviews Materials, 2023 - nature.com
Organ-on-a-chip devices have enabled major breakthroughs in biomedical research, but
they have yet to be successfully translated to the pharmaceutical industry. Traditional …

[HTML][HTML] iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies

VEJM Palasantzas, I Tamargo-Rubio, K Le, J Slager… - Trends in Genetics, 2023 - cell.com
Genome-wide association studies (GWAS) have now correlated hundreds of genetic
variants with complex genetic diseases and drug efficacy. Functional characterization of …