Human disease models in drug development
A Loewa, JJ Feng, S Hedtrich - Nature reviews bioengineering, 2023 - nature.com
Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …
disease models owing to the notoriously high failure rates of the current drug development …
Nature-inspired micropatterns
Micropatterned materials have developed in nature over 3.8 billion years, with remarkable
performance. Nature inspiration is the process of understanding biological mechanisms and …
performance. Nature inspiration is the process of understanding biological mechanisms and …
Biomedical applications of microfluidic devices: a review
Both passive and active microfluidic chips are used in many biomedical and chemical
applications to support fluid mixing, particle manipulations, and signal detection. Passive …
applications to support fluid mixing, particle manipulations, and signal detection. Passive …
Microfluidic organ-on-a-chip: a guide to biomaterial choice and fabrication
UMN Cao, Y Zhang, J Chen, D Sayson, S Pillai… - International journal of …, 2023 - mdpi.com
Organ-on-A-chip (OoAC) devices are miniaturized, functional, in vitro constructs that aim to
recapitulate the in vivo physiology of an organ using different cell types and extracellular …
recapitulate the in vivo physiology of an organ using different cell types and extracellular …
Controlling the biodistribution and clearance of nanomedicines
Nanomedicines improve drug bioavailability, the dose–response relationship, targeting
ability, efficacy and safety compared to conventional freely administered drugs …
ability, efficacy and safety compared to conventional freely administered drugs …
Vat photopolymerization 3D printed microfluidic devices for organ-on-a-chip applications
Organs-on-a-chip, or OoCs, are microfluidic tissue culture devices with micro-scaled
architectures that repeatedly achieve biomimicry of biological phenomena. They are well …
architectures that repeatedly achieve biomimicry of biological phenomena. They are well …
Intelligent biomaterialomics: molecular design, manufacturing, and biomedical applications
Y Yi, HW An, H Wang - Advanced Materials, 2024 - Wiley Online Library
Materialomics integrates experiment, theory, and computation in a high‐throughput manner,
and has changed the paradigm for the research and development of new functional …
and has changed the paradigm for the research and development of new functional …
Nose-on-chip nanobiosensors for early detection of lung cancer breath biomarkers
Lung cancer remains a global health concern, demanding the development of noninvasive,
prompt, selective, and point-of-care diagnostic tools. Correspondingly, breath analysis using …
prompt, selective, and point-of-care diagnostic tools. Correspondingly, breath analysis using …
Clam** strategies for organ-on-a-chip devices
Organ-on-a-chip devices have enabled major breakthroughs in biomedical research, but
they have yet to be successfully translated to the pharmaceutical industry. Traditional …
they have yet to be successfully translated to the pharmaceutical industry. Traditional …
[HTML][HTML] iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies
VEJM Palasantzas, I Tamargo-Rubio, K Le, J Slager… - Trends in Genetics, 2023 - cell.com
Genome-wide association studies (GWAS) have now correlated hundreds of genetic
variants with complex genetic diseases and drug efficacy. Functional characterization of …
variants with complex genetic diseases and drug efficacy. Functional characterization of …