The nuclear envelope (NE) is a specialization of the endoplasmic reticulum with distinct
biochemistry that defines inner and outer membranes connected at a pore membrane that …

Due to their essential functions, dysregulation of nuclear pore complexes (NPCs) is strongly
associated with numerous human diseases, including neurodegeneration and cancer. On a …

Endosomal sorting complex required for transport (ESCRT) is required for maintenance of
nuclear functions and prevention of neurodegenerative diseases. The budding yeast …

Microautophagy degrades cargos in the vacuole by direct engulfment of the vacuolar
membrane. Micronucleophagy selectively degrades a portion of the nucleus in budding …

Intranuclear protein quality control (PQC) is critical for protein homeostasis (or proteostasis)
in non-dividing cells including brain nerve cells, but its molecular mechanism remains …

Liquid‐ordered (Lo) membrane domains have been proposed to play important roles in a
wide variety of biological processes, such as protein sorting and cell signaling. However, the …

Vacuoles and lysosomes are organelles involved in the degradation of cytoplasmic proteins
and organelles. Vacuolar morphology is dynamically regulated by fission and fusion in …

The degradation of nucleolar proteins–nucleophagy–is elicited by nutrient starvation or the
inactivation of target of rapamycin complex 1 (TORC1) protein kinase in budding yeast. Prior …

Maintenance of organelle homeostasis is crucial for cellular function and viability and the
inability of cells to maintain organelle homeostasis is a major driver of age-related diseases …