Migraine: disease characterisation, biomarkers, and precision medicine

M Ashina, GM Terwindt, MAM Al-Karagholi, I De Boer… - The Lancet, 2021 - thelancet.com
Migraine is a disabling neurological disorder, diagnosis of which is based on clinical criteria.
A shortcoming of these criteria is that they do not fully capture the heterogeneity of migraine …

Genetics of migraine: where are we now?

L Grangeon, KS Lange, M Waliszewska-Prosół… - The Journal of …, 2023 - Springer
Migraine is a complex brain disorder explained by the interaction of genetic and
environmental factors. In monogenic migraines, including familial hemiplegic migraine and …

[HTML][HTML] Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

H Hautakangas, BS Winsvold, SE Ruotsalainen… - Nature …, 2022 - nature.com
Migraine affects over a billion individuals worldwide but its genetic underpinning remains
largely unknown. Here, we performed a genome-wide association study of 102,084 …

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

P Gormley, V Anttila, BS Winsvold, P Palta, T Esko… - Nature …, 2016 - nature.com
Migraine is a debilitating neurological disorder affecting around one in seven people
worldwide, but its molecular mechanisms remain poorly understood. There is some debate …

Association between telomere length and risk of cancer and non-neoplastic diseases: a Mendelian randomization study

PC Haycock, S Burgess, A Nounu, J Zheng… - JAMA …, 2017 - jamanetwork.com
Importance The causal direction and magnitude of the association between telomere length
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …

Advances in genetics of migraine

HG Sutherland, CL Albury, LR Griffiths - The journal of headache and pain, 2019 - Springer
Background Migraine is a complex neurovascular disorder with a strong genetic component.
There are rare monogenic forms of migraine, as well as more common polygenic forms; …

Migraine and risk of stroke

LR Øie, T Kurth, S Gulati, DW Dodick - Journal of Neurology …, 2020 - jnnp.bmj.com
Migraine and stroke are two common and heterogeneous neurovascular disorders
responsible for a significant burden for those affected and a great economic cost for the …

Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types

S Chun, A Casparino, NA Patsopoulos… - Nature …, 2017 - nature.com
Most autoimmune-disease-risk effects identified by genome-wide association studies
(GWAS) localize to open chromatin with gene-regulatory activity. GWAS loci are also …

Genetics of migraine: insights into the molecular basis of migraine disorders

HG Sutherland, LR Griffiths - … : The Journal of Head and Face …, 2017 - Wiley Online Library
Migraine is a complex, debilitating neurovascular disorder, typically characterized by
recurring, incapacitating attacks of severe headache often accompanied by nausea and …

[HTML][HTML] Advance in genetics of migraine

I de Boer, AMJM van den Maagdenberg… - Current opinion in …, 2019 - journals.lww.com
Integration of genetic, phenotypic and epigenetic data will help to identify the biological
mechanisms by which genetic factors contribute to migraine pathogenesis. Recent studies …