Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

Obesity, a major risk factor for the development of diabetes mellitus, cardiovascular diseases
and certain types of cancer, arises from a chronic positive energy balance that is often due to …

Protein tyrosine phosphatase–1B (PTP-1B) has been implicated in the negative regulation
of insulin signaling. Disruption of the mouse homolog of the gene encoding PTP-1B yielded …

Protein-tyrosine phosphatase 1B (PTP-1B) is a major protein-tyrosine phosphatase that has
been implicated in the regulation of insulin action, as well as in other signal transduction …

Protein tyrosine phosphatases (PTPs) catalyze the hydrolysis of phosphotyrosine from
specific signal-transducing proteins. Although regulatory mechanisms for protein kinases …

Protein tyrosine phosphatase 1B (PTP1B) is an effective target for the treatment of both type
2 diabetes and obesity; however, targeting PTP1B for drug discovery is challenging because …

Protein tyrosine phosphorylation is a key regulatory process in virtually all aspects of cellular
functions. Dysregulation of protein tyrosine phosphorylation is a major cause of human …

Obesity and type II diabetes are closely linked metabolic syndromes that afflict> 100 million
people worldwide. Although protein tyrosine phosphatase 1B (PTP1B) has emerged as a …

Insulin resistance, the most important characteristic of the type 2 diabetes mellitus (T2DM), is
mostly caused by impairment in the insulin receptor (IR) signal transduction pathway …

Protein tyrosine phosphatases (PTPs) are signaling enzymes that control a diverse array of
cellular processes. Malfunction of PTP activity is associated with a number of human …