Metabolomics in cancer research and emerging applications in clinical oncology
Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …
The Warburg effect: how does it benefit cancer cells?
Cancer cells rewire their metabolism to promote growth, survival, proliferation, and long-term
maintenance. The common feature of this altered metabolism is the increased glucose …
maintenance. The common feature of this altered metabolism is the increased glucose …
The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression
In the early 1920s, Warburg published experimental data on the enhanced conversion of
glucose to pyruvate (followed by lactate formation) even in the presence of abundant oxygen …
glucose to pyruvate (followed by lactate formation) even in the presence of abundant oxygen …
[HTML][HTML] Brown-fat-mediated tumour suppression by cold-altered global metabolism
T Seki, Y Yang, X Sun, S Lim, S **e, Z Guo, W **ong… - Nature, 2022 - nature.com
Glucose uptake is essential for cancer glycolysis and is involved in non-shivering
thermogenesis of adipose tissues,,,,–. Most cancers use glycolysis to harness energy for …
thermogenesis of adipose tissues,,,,–. Most cancers use glycolysis to harness energy for …
Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity
Activated immune cells undergo a metabolic switch to aerobic glycolysis akin to the Warburg
effect, thereby presenting a potential therapeutic target in autoimmune disease. Dimethyl …
effect, thereby presenting a potential therapeutic target in autoimmune disease. Dimethyl …
Hypoxia-modified cancer cell metabolism
While oxygen is critical to the continued existence of complex organisms, extreme levels of
oxygen within a system, known as hypoxia (low levels of oxygen) and hyperoxia (excessive …
oxygen within a system, known as hypoxia (low levels of oxygen) and hyperoxia (excessive …
Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells
AM Hosios, VC Hecht, LV Danai, MO Johnson… - Developmental cell, 2016 - cell.com
Cells must duplicate their mass in order to proliferate. Glucose and glutamine are the major
nutrients consumed by proliferating mammalian cells, but the extent to which these and …
nutrients consumed by proliferating mammalian cells, but the extent to which these and …
4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
ST Liao, C Han, DQ Xu, XW Fu, JS Wang… - Nature …, 2019 - nature.com
Activated macrophages switch from oxidative phosphorylation to aerobic glycolysis, similar
to the Warburg effect, presenting a potential therapeutic target in inflammatory disease. The …
to the Warburg effect, presenting a potential therapeutic target in inflammatory disease. The …
Acetate production from glucose and coupling to mitochondrial metabolism in mammals
Acetate is a major nutrient that supports acetyl-coenzyme A (Ac-CoA) metabolism and thus
lipogenesis and protein acetylation. However, its source is unclear. Here, we report that …
lipogenesis and protein acetylation. However, its source is unclear. Here, we report that …
Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis
How phosphate levels are detected in mammals is unknown. The bone-derived hormone
fibroblast growth factor 23 (FGF23) lowers blood phosphate levels by reducing kidney …
fibroblast growth factor 23 (FGF23) lowers blood phosphate levels by reducing kidney …