Early engagement of the lymphatic system by solid tumors in peripheral, nonlymphoid
tissues is a clinical hallmark of cancer and often forecasts poor prognosis. The significance …

BACKGROUND Blood and lymphatic vessel networks form two arms of the vertebrate
cardiovascular system that play complementary roles in body homeostasis maintenance and …

Secreted extracellular vesicles (EVs) influence the tumor microenvironment and promote
distal metastasis. Here we analyzed the involvement of melanoma-secreted EVs in lymph …

The lymphatic system, composed of initial and collecting lymphatic vessels as well as lymph
nodes that are present in almost every tissue of the human body, acts as an essential …

Tumour‐draining lymph nodes (LNs) undergo massive remodelling including expansion of
the lymphatic sinuses, a process that has been linked to lymphatic metastasis by creation of …

Lymph nodes (LNs) are important hubs for metastatic cell arrest and growth, immune
modulation, and secondary dissemination to distant sites through a series of mechanisms …

Cancer metastasis is the process by which primary cancer cells invade through the
lymphatic or blood vessels to distant sites. The molecular mechanisms by which cancer cells …

Lymph nodes (LNs) are highly organized secondary lymphoid organs that mediate adaptive
immune responses to antigens delivered via afferent lymphatic vessels. Lymphatic …

Lymph nodes are the most common sites of metastasis in cancer patients. Nodal disease
status provides great prognostic power, but how lymph node metastases should be treated …

Secondary lymphoid organs, such as lymph nodes, harbor highly specialized and
compartmentalized niches. These niches are optimized to facilitate the encounter of naive …