Cells measure a vast variety of signals, from their environment's stiffness to chemical
concentrations and gradients; physical principles strongly limit how accurately they can do …

Elongated, weakly interacting, apolar, fibroblast cells (mouse fibroblasts NIH-3T3) cultured
at confluence align together, forming large domains (correlation length∼ 500 μm) where …

Transmission heterogeneity, whereby a disproportionate fraction of pathogen transmission
events result from a small number of individuals or geographic locations, is an inherent …

Coordinated responses to environmental stimuli are critical for multicellular organisms. To
overcome the obstacles of cell-to-cell heterogeneity and noisy signaling dynamics within …

Cells use biochemical networks to translate environmental information into intracellular
responses. These responses can be highly dynamic, but how the information is encoded in …

β cells are biologically essential for humans and other vertebrates. Because their
functionality arises from cell-cell interactions, they are also a model system for collective …

Residing in the islets of Langerhans in the pancreas, β cells contribute to glucose
homeostasis by managing the body's insulin supply. Although it has been acknowledged …

We typically think of cells as responding to external signals independently by regulating their
gene expression levels, yet they often locally exchange information and coordinate. Can …

The cellular cytoskeleton relies on diverse populations of motors, filaments, and binding
proteins acting in concert to enable nonequilibrium processes ranging from mitosis to …

Multicellular synchronization is a ubiquitous phenomenon in living systems. However, how
noisy and heterogeneous behaviors of individual cells are integrated across a population …