[HTML][HTML] Transient, nano-scale, liquid-like molecular assemblies coming of age
A Kusumi, TA Tsunoyama, KGN Suzuki… - Current Opinion in Cell …, 2024 - Elsevier
This review examines the dynamic mechanisms underlying cellular signaling,
communication, and adhesion via transient, nano-scale, liquid-like molecular assemblies on …
communication, and adhesion via transient, nano-scale, liquid-like molecular assemblies on …
Location bias: a “hidden variable” in GPCR pharmacology
G protein‐coupled receptors (GPCRs) are the largest family of transmembrane receptors
and primarily signal through two main effector proteins: G proteins and β‐arrestins. Many …
and primarily signal through two main effector proteins: G proteins and β‐arrestins. Many …
Molecular insights into atypical modes of β-arrestin interaction with seven transmembrane receptors
β-arrestins (βarrs) are multifunctional proteins involved in signaling and regulation of seven
transmembrane receptors (7TMRs), and their interaction is driven primarily by agonist …
transmembrane receptors (7TMRs), and their interaction is driven primarily by agonist …
[HTML][HTML] From membrane to nucleus: A three-wave hypothesis of cAMP signaling
For many decades, our understanding of G protein-coupled receptor (GPCR) activity and
cyclic AMP (cAMP) signaling was limited exclusively to the plasma membrane. However, a …
cyclic AMP (cAMP) signaling was limited exclusively to the plasma membrane. However, a …
Molecular mechanism of β-arrestin-2 pre-activation by phosphatidylinositol 4, 5-bisphosphate
K Kim, KY Chung - EMBO reports, 2024 - embopress.org
Phosphorylated residues of G protein-coupled receptors bind to the N-domain of arrestin,
resulting in the release of its C-terminus. This induces further allosteric conformational …
resulting in the release of its C-terminus. This induces further allosteric conformational …
Functional consequences of spatial, temporal and ligand bias of G protein-coupled receptors
AD Tóth, G Turu, L Hunyady - Nature Reviews Nephrology, 2024 - nature.com
G protein-coupled receptors (GPCRs) regulate every aspect of kidney function by mediating
the effects of various endogenous and exogenous substances. A key concept in GPCR …
the effects of various endogenous and exogenous substances. A key concept in GPCR …
Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system
Chemokine receptors constitute an important subfamily of G protein-coupled receptors
(GPCRs), and they are critically involved in a broad range of immune response …
(GPCRs), and they are critically involved in a broad range of immune response …
Effect of hormone-induced plasma membrane phosphatidylinositol 4, 5-bisphosphate depletion on receptor endocytosis suggests the importance of local regulation in …
Abstract Phosphatidylinositol 4, 5-bisphosphate (PIP2) has been shown to be critical for the
endocytosis of G protein-coupled receptors (GPCRs). We have previously demonstrated that …
endocytosis of G protein-coupled receptors (GPCRs). We have previously demonstrated that …
The path to the G protein‐coupled receptor structural landscape: Major milestones and future directions
MM Kogut‐Günthel, Z Zara, A Nicoli… - British Journal of …, 2024 - Wiley Online Library
G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing
signals from the extracellular environment to the inside of the cell. They mediate the effects …
signals from the extracellular environment to the inside of the cell. They mediate the effects …
Arrestin‐centred interactions at the membrane and their conformational determinants
More than 30 years after their discovery, arrestins are recognised multiprotein scaffolds that
play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling …
play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling …