The role of electrical stimulation for rehabilitation and regeneration after spinal cord injury

BA Karamian, N Siegel, B Nourie, MD Serruya… - Journal of Orthopaedics …, 2022 - Springer
Electrical stimulation is used to elicit muscle contraction and can be utilized for
neurorehabilitation following spinal cord injury when paired with voluntary motor training …

Neuromodulation in the restoration of function after spinal cord injury

ND James, SB McMahon, EC Field-Fote… - The Lancet …, 2018 - thelancet.com
Neuromodulation, the use of electrical interfaces to alter neuronal activity, has been
successful as a treatment approach in several neurological disorders, including deep brain …

Neuromodulation of lumbosacral spinal networks enables independent step** after complete paraplegia

ML Gill, PJ Grahn, JS Calvert, MB Linde, IA Lavrov… - Nature medicine, 2018 - nature.com
Spinal sensorimotor networks that are functionally disconnected from the brain because of
spinal cord injury (SCI) can be facilitated via epidural electrical stimulation (EES) to restore …

Self-assisted standing enabled by non-invasive spinal stimulation after spinal cord injury

DG Sayenko, M Rath, AR Ferguson… - Journal of …, 2019 - liebertpub.com
Neuromodulation of spinal networks can improve motor control after spinal cord injury (SCI).
The objectives of this study were to (1) determine whether individuals with chronic paralysis …

Transcutaneous electrical spinal stimulation promotes long-term recovery of upper extremity function in chronic tetraplegia

F Inanici, S Samejima, P Gad… - … on Neural Systems …, 2018 - ieeexplore.ieee.org
Upper extremity function is the highest priority of tetraplegics for improving quality of life. We
aim to determine the therapeutic potential of transcutaneous electrical spinal cord …

Common neural structures activated by epidural and transcutaneous lumbar spinal cord stimulation: Elicitation of posterior root-muscle reflexes

US Hofstoetter, B Freundl, H Binder, K Minassian - PloS one, 2018 - journals.plos.org
Epidural electrical stimulation of the lumbar spinal cord is currently regaining momentum as
a neuromodulation intervention in spinal cord injury (SCI) to modify dysregulated …

Non-invasive activation of cervical spinal networks after severe paralysis

P Gad, S Lee, N Terrafranca, H Zhong… - Journal of …, 2018 - liebertpub.com
Paralysis of the upper extremities following cervical spinal cord injury (SCI) significantly
impairs one's ability to live independently. While regaining hand function or gras** ability …

Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease

AK Vose, JF Welch, J Nair, EA Dale, EJ Fox… - Experimental …, 2022 - Elsevier
We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …

Transcutaneous spinal cord stimulation and motor rehabilitation in spinal cord injury: a systematic review

A Megía García, D Serrano-Muñoz… - … and neural repair, 2020 - journals.sagepub.com
Background. Epidural spinal electrical stimulation at the lumbar spinal level evokes rhythmic
muscle activation of lower-limb antagonists, attributed to the central pattern generator …

Neuroregeneration and plasticity: a review of the physiological mechanisms for achieving functional recovery postinjury

PG Nagappan, H Chen, DY Wang - Military Medical Research, 2020 - Springer
Neuronal networks, especially those in the central nervous system (CNS), evolved to
support extensive functional capabilities while ensuring stability. Several physiological …