Excited (triplet) states offer a myriad of attractive synthetic pathways, including
cycloadditions, selective homolytic bond cleavages and strain-release chemistry …

The concept of strain in organic compounds is as old as modern organic chemistry and was
initially introduced to justify the synthetic setbacks along the synthesis of small ring systems …

For more than one century, photochemical [2+ 2]-cycloadditions have been used by
synthetic chemists to make cyclobutanes, four-membered carbon-based rings. In this …

Benzenes, the most ubiquitous structural moiety in marketed small-molecule drugs, are
frequently associated with poor 'drug-like'properties, including metabolic instability, and poor …

The benzene moiety is the most prevalent ring system in marketed drugs, underscoring its
historic popularity in drug design either as a pharmacophore or as a scaffold that projects …

The replacement of benzene rings with sp 3-hybridized bioisosteres in drug candidates
generally improves pharmacokinetic properties while retaining biological activity,,,–. Rigid …

Bicyclo [2.1. 1] hexanes (BCHs) represent an intriguing class of structurally rigid
hydrocarbons that can serve as the bioisosteres of benzenoids in medicinal chemistry …

Small-ring cage hydrocarbons are popular bioisosteres (molecular replacements) for
commonly found para-substituted benzene rings in drug design. The utility of these cage …

Synthesis of bicyclic scaffolds has attracted growing interest because they are of high
importance in modern pharmaceutical development. Here we report a strategy to access …

We report the use of photocatalysis for the homolytic ring-opening of carbonyl
cyclopropanes. In contrast to previous studies, our approach does not require a metal …