All proliferating cells need to match metabolism, growth and cell cycle progression with
nutrient availability to guarantee cell viability in spite of a changing environment. In yeast, a …

Background Yeast cells have developed a variety of mechanisms to regulate the activity of
metabolic enzymes in order to adjust their metabolism in response to genetic and …

Stressed cells coordinate a multi‐faceted response spanning many levels of physiology. Yet
knowledge of the complete stress‐activated regulatory network as well as design principles …

In eukaryotes, nutrient availability and metabolism are coordinated by sensing mechanisms
and signaling pathways, which influence a broad set of cellular functions such as …

Mitochondria are central to numerous metabolic pathways whereby mitochondrial
dysfunction has a profound impact and can manifest in disease. The consequences of …

Mitochondria play essential metabolic functions in eukaryotes. Although their major role is
the generation of energy in the form of ATP, they are also involved in maintenance of cellular …

As centers for energy production and essential biosynthetic activities, mitochondria are vital
for cell growth and proliferation. Accumulating evidence suggests an integrated regulation of …

Control of the protein phosphorylation status is a major mechanism for regulation of cellular
processes, and its alteration often lead to functional disorders. Ppz1, a protein phosphatase …

Mass spectrometry allows quantification of tens of thousands of phosphorylation sites from
minute amounts of cellular material. Despite this wealth of information, our understanding of …

Abstract Background Protein phosphatase 2A (PP2A) is a family of conserved
serine/threonine phosphatases involved in several essential aspects of cell growth and …