Microglia and astrocytes are regarded as active participants in the central nervous system
under various neuropathological conditions, including Alzheimer's disease (AD). Both …

Some individuals are able to maintain their cognitive abilities despite the presence of
significant Alzheimer's Disease (AD) neuropathological changes. This discrepancy between …

Pervasive neuroinflammation occurs in many neurodegenerative diseases, including
Alzheimer's disease (AD). SPI1/PU. 1 is a transcription factor located at a genome-wide …

Odd elasticity describes active elastic systems whose stress-strain relationship is not
compatible with a potential energy. As the requirement of energy conservation is lifted from …

Reactive microglia are observed with aging and in Lewy body disorders, including within the
olfactory bulb of men with Parkinson's disease. However, the functional impact of microglia …

Microglia, traditionally regarded as innate immune cells in the brain, drive
neuroinflammation and synaptic dysfunctions in the early phases of Alzheimer disease (AD) …

The central nervous system (CNS) is an essential hub for neuronal communication. As a
major component of the CNS, glial cells are vital in the maintenance and regulation of …

Background N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) is a neurotoxin widely
used to induce PD models, but the effect of MPTP on the cells and genes of PD has not been …

Previous studies have demonstrated the dynamic changes in chromatin structure during
retinal development correlate with changes in gene expression. However, those studies lack …

Abstract Background In Alzheimer's disease (AD), microglia surround extracellular plaques
and mount a sustained inflammatory response, contributing to the pathogenesis of the …