The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer

EP Murchison, C Tovar, A Hsu, HS Bender… - Science, 2010 - science.org
The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a
transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is …

Wildlife cancer: a conservation perspective

D McAloose, AL Newton - Nature reviews cancer, 2009 - nature.com
Until recently, cancer in wildlife was not considered to be a conservation concern. However,
with the identification of Tasmanian devil facial tumour disease, sea turtle …

The evolution of two transmissible cancers in Tasmanian devils

MR Stammnitz, K Gori, YM Kwon, E Harry, FJ Martin… - Science, 2023 - science.org
Tasmanian devils have spawned two transmissible cancer lineages, named devil facial
tumor 1 (DFT1) and devil facial tumor 2 (DFT2). We investigated the genetic diversity and …

A second transmissible cancer in Tasmanian devils

RJ Pye, D Pemberton, C Tovar, JMC Tubio… - Proceedings of the …, 2016 - pnas.org
Clonally transmissible cancers are somatic cell lineages that are spread between
individuals via the transfer of living cancer cells. There are only three known naturally …

[HTML][HTML] Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer

EP Murchison, OB Schulz-Trieglaff, Z Ning… - Cell, 2012 - cell.com
Summary The Tasmanian devil (Sarcophilus harrisii), the largest marsupial carnivore, is
endangered due to a transmissible facial cancer spread by direct transfer of living cancer …

Density trends and demographic signals uncover the long‐term impact of transmissible cancer in Tasmanian devils

BT Lazenby, MW Tobler, WE Brown… - Journal of Applied …, 2018 - Wiley Online Library
Monitoring the response of wild mammal populations to threatening processes is
fundamental to effective conservation management. This is especially true for infectious …

Tumors of the nervous system

RJ Higgins, AW Bollen, PJ Dickinson… - Tumors in domestic …, 2016 - Wiley Online Library
Primary neoplasms of the nervous system are relatively rare in most domestic animal
species with the exception of the dog and, to a lesser extent, the cat. Dogs and cats live …

Transmission dynamics of Tasmanian devil facial tumor disease may lead to disease‐induced extinction

H McCallum, M Jones, C Hawkins, R Hamede… - Ecology, 2009 - Wiley Online Library
Most pathogens threatening to cause extinction of a host species are maintained on one or
more reservoir hosts, in addition to the species that is threatened by disease. Further, most …

Transmission of a fatal clonal tumor by biting occurs due to depleted MHC diversity in a threatened carnivorous marsupial

HV Siddle, A Kreiss, MDB Eldridge, E Noonan… - Proceedings of the …, 2007 - pnas.org
A fatal transmissible tumor spread between individuals by biting has emerged in the
Tasmanian devil (Sarcophilus harrisii), a carnivorous marsupial. Here we provide genetic …

Disease and the dynamics of extinction

H McCallum - … Transactions of the Royal Society B …, 2012 - royalsocietypublishing.org
Invading infectious diseases can, in theory, lead to the extinction of host populations,
particularly if reservoir species are present or if disease transmission is frequency …