Synthetic glycans to improve current glycoconjugate vaccines and fight antimicrobial resistance

L Del Bino, KE Østerlid, DY Wu, F Nonne… - Chemical …, 2022 - ACS Publications
Antimicrobial resistance (AMR) is emerging as the next potential pandemic. Different
microorganisms, including the bacteria Acinetobacter baumannii, Clostridioides difficile …

Wall teichoic acid in Staphylococcus aureus host interaction

R van Dalen, A Peschel, NM van Sorge - Trends in microbiology, 2020 - cell.com
Staphylococcus aureus is a major opportunistic human pathogen that frequently causes
disease in community and hospital settings. Nasal colonization is an important risk factor for …

β-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium

JF Fisher, S Mobashery - Chemical reviews, 2020 - ACS Publications
The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …

Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation

AR Cruz, MA Boer, J Strasser, SA Zwarthoff… - Proceedings of the …, 2021 - pnas.org
Immunoglobulin (Ig) G molecules are essential players in the human immune response
against bacterial infections. An important effector of IgG-dependent immunity is the induction …

Glycoconjugate vaccines against antimicrobial resistant pathogens

C Sorieul, M Dolce, MR Romano, J Codée… - Expert review of …, 2023 - Taylor & Francis
Introduction Antimicrobial resistance (AMR) is responsible for the death of millions
worldwide and stands as a major threat to our healthcare systems, which are heavily reliant …

Staphylococcus epidermidis clones express Staphylococcus aureus-type wall teichoic acid to shift from a commensal to pathogen lifestyle

X Du, J Larsen, M Li, A Walter, C Slavetinsky… - Nature …, 2021 - nature.com
Most clonal lineages of Staphylococcus epidermidis are commensals present on human
skin and in the nose. However, some globally spreading healthcare-associated and …

A multi-enzyme machine polymerizes the Haemophilus influenzae type b capsule

JO Cifuente, J Schulze, A Bethe… - Nature Chemical …, 2023 - nature.com
Bacterial capsules have critical roles in host-pathogen interactions. They provide a
protective envelope against host recognition, leading to immune evasion and bacterial …

Structure and function of Listeria teichoic acids and their implications

ET Sumrall, AP Keller, Y Shen… - Molecular …, 2020 - Wiley Online Library
Teichoic acids (TAs) are the most abundant glycopolymers in the cell wall of Listeria, an
opportunistic Gram‐positive pathogen that causes severe foodborne infections. Two …

Macrocycle-antibiotic hybrids: A path to clinical candidates

AS Surur, D Sun - Frontiers in Chemistry, 2021 - frontiersin.org
The tale of abate in antibiotics continued defense mechanisms that chaperone the rise of
drug-defying superbugs—on the other hand, the astray in antibacterial drug discovery and …

Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro and in vivo biofilm

L de Vor, B van Dijk, K van Kessel, JS Kavanaugh… - Elife, 2022 - elifesciences.org
Implant-associated Staphylococcus aureus infections are difficult to treat because of biofilm
formation. Bacteria in a biofilm are often insensitive to antibiotics and host immunity …