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Synthetic glycans to improve current glycoconjugate vaccines and fight antimicrobial resistance
L Del Bino, KE Østerlid, DY Wu, F Nonne… - Chemical …, 2022 - ACS Publications
Antimicrobial resistance (AMR) is emerging as the next potential pandemic. Different
microorganisms, including the bacteria Acinetobacter baumannii, Clostridioides difficile …
microorganisms, including the bacteria Acinetobacter baumannii, Clostridioides difficile …
Wall teichoic acid in Staphylococcus aureus host interaction
Staphylococcus aureus is a major opportunistic human pathogen that frequently causes
disease in community and hospital settings. Nasal colonization is an important risk factor for …
disease in community and hospital settings. Nasal colonization is an important risk factor for …
β-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium
JF Fisher, S Mobashery - Chemical reviews, 2020 - ACS Publications
The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …
Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation
Immunoglobulin (Ig) G molecules are essential players in the human immune response
against bacterial infections. An important effector of IgG-dependent immunity is the induction …
against bacterial infections. An important effector of IgG-dependent immunity is the induction …
Glycoconjugate vaccines against antimicrobial resistant pathogens
C Sorieul, M Dolce, MR Romano, J Codée… - Expert review of …, 2023 - Taylor & Francis
Introduction Antimicrobial resistance (AMR) is responsible for the death of millions
worldwide and stands as a major threat to our healthcare systems, which are heavily reliant …
worldwide and stands as a major threat to our healthcare systems, which are heavily reliant …
Staphylococcus epidermidis clones express Staphylococcus aureus-type wall teichoic acid to shift from a commensal to pathogen lifestyle
Most clonal lineages of Staphylococcus epidermidis are commensals present on human
skin and in the nose. However, some globally spreading healthcare-associated and …
skin and in the nose. However, some globally spreading healthcare-associated and …
A multi-enzyme machine polymerizes the Haemophilus influenzae type b capsule
JO Cifuente, J Schulze, A Bethe… - Nature Chemical …, 2023 - nature.com
Bacterial capsules have critical roles in host-pathogen interactions. They provide a
protective envelope against host recognition, leading to immune evasion and bacterial …
protective envelope against host recognition, leading to immune evasion and bacterial …
Structure and function of Listeria teichoic acids and their implications
Teichoic acids (TAs) are the most abundant glycopolymers in the cell wall of Listeria, an
opportunistic Gram‐positive pathogen that causes severe foodborne infections. Two …
opportunistic Gram‐positive pathogen that causes severe foodborne infections. Two …
Macrocycle-antibiotic hybrids: A path to clinical candidates
The tale of abate in antibiotics continued defense mechanisms that chaperone the rise of
drug-defying superbugs—on the other hand, the astray in antibacterial drug discovery and …
drug-defying superbugs—on the other hand, the astray in antibacterial drug discovery and …
Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro and in vivo biofilm
L de Vor, B van Dijk, K van Kessel, JS Kavanaugh… - Elife, 2022 - elifesciences.org
Implant-associated Staphylococcus aureus infections are difficult to treat because of biofilm
formation. Bacteria in a biofilm are often insensitive to antibiotics and host immunity …
formation. Bacteria in a biofilm are often insensitive to antibiotics and host immunity …