Abstract Safety tested Modified Vaccinia virus Ankara (MVA) is licensed as third-generation
vaccine against smallpox and serves as a potent vector system for development of new …

Recent developments in the use of viruses as vaccine vectors have been facilitated by a
better understanding of viral biology. Advances occur as we gain greater insight into the …

The complete genomic DNA sequence of the highly attenuated vaccinia strain modified
vaccinia Ankara (MVA) was determined. The genome of MVA is 178 kb in length …

Since the discovery in 1796 by Edward Jenner of vaccinia virus as a way to prevent and
finally eradicate smallpox, the concept of using a virus to fight another virus has evolved into …

Vaccinia virus, no longer required for immunization against smallpox, now serves as a
unique vector for expressing genes within the cytoplasm of mammalian cells. As a research …

Vaccinia virus, a member of the poxvirus family, is widely used as a mammalian cell
expression vector. Vaccinia virus replicates in the cytoplasm and has its own transcriptional …

Immunization with irradiated sporozoites can protect against malaria infection and intensive
efforts are aimed at reproducing this effect with subunit vaccines. A particular sequence of …

Modified virus Ankara (MVA) is a vaccinia virus (VV) strain that was attenuated by serial
passage through chick embryo fibroblasts (CEFs) and contains six large genomic deletions …

Modified vaccinia virus Ankara (MVA), attenuated by over 500 passages in primary chick
embyro fibroblasts (CEF), is presently being used as a safe expression vector. We compared …

Tuberculosis (TB), caused by respiratory infection with Mycobacterium tuberculosis, remains
a major global health threat. The only licensed TB vaccine, the one-hundred-year-old Bacille …