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Animal models of major depression: drawbacks and challenges
Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …
Rodent models of post-traumatic stress disorder: behavioral assessment
Although the etiology and expression of psychiatric disorders are complex, mammals show
biologically preserved behavioral and neurobiological responses to valent stimuli which …
biologically preserved behavioral and neurobiological responses to valent stimuli which …
Animal models of depression: what can they teach us about the human disease?
Depression is apparently the most common psychiatric disease among the mood disorders
affecting about 10% of the adult population. The etiology and pathogenesis of depression …
affecting about 10% of the adult population. The etiology and pathogenesis of depression …
Sex differences in antidepressant efficacy
TA LeGates, MD Kvarta, SM Thompson - Neuropsychopharmacology, 2019 - nature.com
Sex differences have been observed across many psychiatric diseases, especially mood
disorders. For major depression, the most prevalent psychiatric disorder, females show a …
disorders. For major depression, the most prevalent psychiatric disorder, females show a …
[HTML][HTML] Interaction between circadian rhythms and stress
CE Koch, B Leinweber, BC Drengberg, C Blaum… - Neurobiology of …, 2017 - Elsevier
Life on earth has adapted to the day-night cycle by evolution of internal, so-called circadian
clocks that adjust behavior and physiology to the recurring changes in environmental …
clocks that adjust behavior and physiology to the recurring changes in environmental …
[PDF][PDF] Sex differences in the HPA axis
The hypothalamic-pituitary-adrenal (HPA) axis is a major component of the systems that
respond to stress, by coordinating the neuroendocrine and autonomic responses. Tightly …
respond to stress, by coordinating the neuroendocrine and autonomic responses. Tightly …
[HTML][HTML] Stress, social behavior, and resilience: insights from rodents
The neurobiology of stress and the neurobiology of social behavior are deeply intertwined.
The social environment interacts with stress on almost every front: social interactions can be …
The social environment interacts with stress on almost every front: social interactions can be …
Establishment of a repeated social defeat stress model in female mice
A Takahashi, JR Chung, S Zhang, H Zhang… - Scientific reports, 2017 - nature.com
Numerous studies have employed repeated social defeat stress (RSDS) to study the
neurobiological mechanisms of depression in rodents. An important limitation of RSDS …
neurobiological mechanisms of depression in rodents. An important limitation of RSDS …
A novel method for chronic social defeat stress in female mice
Historically, preclinical stress studies have often omitted female subjects, despite evidence
that women have higher rates of anxiety and depression. In rodents, many stress …
that women have higher rates of anxiety and depression. In rodents, many stress …
Sex differences in anxiety and emotional behavior
NC Donner, CA Lowry - Pflügers Archiv-European Journal of Physiology, 2013 - Springer
Research has elucidated causal links between stress exposure and the development of
anxiety disorders, but due to the limited use of female or sex-comparative animal models …
anxiety disorders, but due to the limited use of female or sex-comparative animal models …