Like the obesity epidemic, our understanding of adipocytes and adipose tissue is
expanding. Just in the past decade, substantial advances have led to new insights into the …

Lipodystrophy is a group of clinically heterogeneous, inherited or acquired, disorders
characterized by complete or partial absence of subcutaneous adipose tissue that may …

Lipodystrophies are rare, heterogeneous, genetic or acquired, disorders characterised by
varying degrees of body fat loss and associated metabolic complications, including insulin …

In mammalian cell nuclei, the nuclear lamina (NL) underlies the nuclear envelope (NE) to
maintain nuclear structure. The nuclear lamins, the major structural components of the NL …

Type 2 familial partial lipodystrophy (FPLD2) is a laminopathic lipodystrophy due to
pathogenic variants in the LMNA gene. Its rarity implies that it is not well-known. The aim of …

Context Lipodystrophy syndromes are a heterogeneous group of rare genetic or acquired
disorders characterized by generalized or partial loss of adipose tissue. LMNA-related …

Purpose To evaluate the effects of metreleptin in patients with partial lipodystrophy (PL).
Methods Patients aged≥ 6 months with PL, circulating leptin< 12.0 ng/mL, and diabetes …

Lipodystrophy syndromes are a heterogeneous group of diseases, characterized by
selective absence of adipose tissue. In one sense, these diseases are lipid-partitioning …

Purpose of review This article focuses on recent progress in understanding the genetics of
lipodystrophy syndromes, the pathophysiology of severe metabolic abnormalities caused by …

Context Polycystic ovary syndrome (PCOS) is a common, heritable endocrinopathy that is a
common cause of anovulatory infertility in reproductive age women. Variants in LMNA cause …