Psychopathology emerges from the dynamic interplay of physiological and mental
processes and ecological context. It can be seen as a failure of recursive, homeostatic …

Psychiatric disorders exhibit an enormous burden on the health care systems worldwide
accounting for around one-third of years lost due to disability among adults. Their etiology is …

Lithium is the gold standard therapy for Bipolar Disorder (BD) but its effectiveness differs
widely between individuals. The molecular mechanisms underlying treatment response …

Systematic reviews (SRs) of preclinical studies are marked with poor methodological quality.
In vitro studies lack assessment tools to improve the quality of preclinical research. This …

Objective Mood stabilizers are psychotropic drugs mainly used to treat bipolar disorder in
the acute phase or for maintenance therapy to prevent relapse. In clinical practice, mood …

Background Metabolic side effects of psychotropic medications are a major drawback to
patients' successful treatment. Using an epigenome-wide approach, we aimed to investigate …

In this study, we investigate the epigenetic mechanisms associated with current suicidal
ideation. Gene expression changes have been found in post-mortem brain of suicide …

Mutations occurring in the MeCp2, CDKL5 and BDNF genes have been linked to
epileptogenesis in various epilepsy syndromes. This study employed bioinformatics analysis …

Background: A large body of evidence suggests that epigenetic modification including DNA
methylation plays a critical role in BD's pathogenesis while the identification of methylation …

Sodium valproate (VPA) is a histone deacetylase (HDAC) inhibitor, widely prescribed in the
treatment of bipolar disorder, and yet the precise modes of therapeutic action for this drug …