Senescence is a cellular state in which cells undergo persistent cell cycle arrest in response
to nonlethal stress. In the treatment of cancer, senescence induction is a potent method of …

Diffuse intrinsic pontine glioma (DIPG) is a childhood malignancy of the brainstem with a
dismal prognosis. Despite recent advances in its understanding at the molecular level, the …

Cellular senescence underlies many aging-related pathologies, but its heterogeneity poses
challenges for studying and targeting senescent cells. We present here a machine learning …

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, yet it
remains refractory to systemic therapy. Elimination of senescent cells has emerged as a …

B-cell-specific Moloney murine leukemia virus integration region 1 (Bmi-1, also known as
RNF51 or PCGF4) is one of the important members of the PcG gene family, and is involved …

Cellular senescence in cancer development is known to have tumor‐suppressive and tumor‐
promoting roles. Recent studies have revealed numerous molecular mechanisms of …

The study of cell senescence is a burgeoning field. Senescent cells can modify the cellular
microenvironment through the secretion of a plethora of biologically active products referred …

Brain health is the humans' primary goal in achieving health and longevity. Brainstem
glioma (BSG) has a high disability and mortality rate, posing a serious threat to children's …

Diffuse midline gliomas (DMGs) including diffuse intrinsic pontine gliomas (DIPGs) bearing
lysine-to-methionine mutations in histone H3 at lysine 27 (H3K27M) are lethal childhood …

Background Diffuse intrinsic pontine glioma (DIPG) is the most common and deadliest
pediatric brainstem tumor and is difficult to treat with chemotherapy in part due to the blood …