The completion of the Human Genome Project has provided a foundational blueprint for
understanding human life. Nonetheless, understanding the intricate mechanisms through …

Neurotoxicity studies aim at understanding the toxic effects and mechanisms of toxicants to
human central nervous systems (CNS). However, human brains are the most complex …

The adult human brain comprises more than a thousand distinct neuronal and glial cell
types, a diversity that emerges during early brain development. To reveal the precise …

Background Melanoma is typically regarded as the most dangerous form of skin cancer.
Although surgical removal of in situ lesions can be used to effectively treat metastatic …

Background Extensive research has established the significant correlations between cancer-
associated fibroblasts (CAFs) and various stages of cancer development, including initiation …

Differential RNA expression is becoming increasingly valuable in evaluating tumor
heterogeneity for a better understanding of malignant tumors and guiding personalized …

The worldwide prevalence of pancreatic cancer has been rising in recent decades, and its
prognosis has not improved much. The imbalance of substance and energy metabolism in …

The regulation of fate decisions in progenitor cells lays the foundation for the generation of
neuronal diversity and the formation of specialized circuits with remarkable processing …

The mammalian cerebral cortex contains an extraordinary diversity of cell types that emerge
by implementing different developmental programs. Delineating when and how cellular …

Mitochondria play a crucial role in numerous biological processes; however, limited
methods and research have focused on revealing mitochondrial heterogeneity at the single …