Carcinogenesis: Failure of resolution of inflammation?

A Fishbein, BD Hammock, CN Serhan… - Pharmacology & …, 2021 - Elsevier
Inflammation in the tumor microenvironment is a hallmark of cancer and is recognized as a
key characteristic of carcinogens. However, the failure of resolution of inflammation in …

Pentapeptide cRGDfK-surface engineered nanostructured lipid carriers as an efficient tool for targeted delivery of tyrosine kinase inhibitor for battling hepatocellular …

P Deepak, P Kumar, P Pandey, DK Arya… - International Journal …, 2023 - Taylor & Francis
Background Antitumor research aims to efficiently target hepatocarcinoma cells (HCC) for
drug delivery. Nanostructured lipid carriers (NLCs) are promising for active tumour targeting …

Poly(lactic-co-glycolic acid)-loaded nanoparticles of betulinic acid for improved treatment of hepatic cancer: characterization, in vitro and in vivo evaluations

P Kumar, AK Singh, V Raj, A Rai… - International journal …, 2018 - Taylor & Francis
Purpose The application of betulinic acid (B), a potent antineoplastic agent, is limited due to
poor bioavailability, short plasma half-life and inappropriate tissue distribution. Thus, we …

Vinpocetine mitigates DMH-induce pre-neoplastic colon damage in rats through inhibition of pro-inflammatory cytokines

AB Sonkar, P Kumar, A Kumar, AK Gautam… - International …, 2023 - Elsevier
Colorectal cancer (CRC) is currently recognized as the third most prevalent cancer
worldwide. Vinpocetine is a synthetic derivative of the vinca alkaloid vincamine. It has been …

Inflammatory auxo-action in the stem cell division theory of cancer

Y Luo, JH **ao - PeerJ, 2023 - peerj.com
Acute inflammation is a beneficial response to the changes caused by pathogens or injuries
that can eliminate the source of damage and restore homeostasis in damaged tissues …

A novel quinazoline derivative exhibits potent anticancer cytotoxicity via apoptosis and inhibition of angiogenesis in DMBA‐induced mammary gland carcinoma

S Rani, R Trivedi, MN Ansari… - … of Biochemical and …, 2024 - Wiley Online Library
Mammary gland carcinoma is one of the most prevalent and deadly diseases among women
globally. It is a type of solid malignant tumor. In this malignant tumor, the microenvironment …

Assessments of in vitro and in vivo antineoplastic potentials of β-sitosterol-loaded PEGylated niosomes against hepatocellular carcinoma

R Nisha, P Kumar, AK Gautam, H Bera… - Journal of Liposome …, 2020 - Taylor & Francis
Abstract β-sitosterol (BS), a phytosterol, exhibits ameliorative effects on hepatocellular
carcinoma (HCC) due to its antioxidant activities. However, its poor aqueous solubility and …

Preclinical Evaluation of Dimethyl Itaconate Against Hepatocellular Carcinoma via Activation of the e/iNOS-Mediated NF-κB–Dependent Apoptotic Pathway

AK Gautam, P Kumar, R Raj, D Kumar… - Frontiers in …, 2022 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most common tumors affecting a large
population worldwide, with the fifth and seventh greatest mortality rates among men and …

The pharmacological effect of apricot seeds extracts and amygdalin in experimentally induced liver damage and hepatocellular carcinoma

A Ramadan, G Kamel, NE Awad… - Journal of …, 2020 - herbmedpharmacol.com
Abstract Introduction: Apricot (Prunus armeniaca L.) has been widely used for the treatment
of several disorders such as liver diseases, but the hepatoprotective and anticancer …

[HTML][HTML] Ameliorative effect of fluvoxamine against colon carcinogenesis via COX-2 blockade with oxidative and metabolic stress reduction at the cellular, molecular …

P Kumar, M Kumar, AK Gautam, AB Sonkar, A Verma… - BBA advances, 2022 - Elsevier
Abstract Fluvoxamine's (FLX's) anticancer potential was investigated in pre-clinical research
utilizing a DMH-induced colorectal cancer (CRC) rat model. qRT-PCR and immunoblotting …