Progressive bladder remodeling due to bladder outlet obstruction: a systematic review of morphological and molecular evidences in humans

F Fusco, M Creta, C De Nunzio, V Iacovelli… - BMC urology, 2018 - Springer
Background Bladder outlet obstruction is a common urological condition. We aimed to
summarize available evidences about bladder outlet obstruction-induced molecular and …

The link between vascular dysfunction, bladder ischemia, and aging bladder dysfunction

KE Andersson, DB Boedtkjer… - Therapeutic advances in …, 2017 - journals.sagepub.com
The vascular supply to the human bladder is derived mainly from the superior and inferior
vesical arteries, the latter being directly connected to the internal iliac artery. Aging is …

Functional consequences of chronic bladder ischemia

O Yamaguchi, M Nomiya… - Neurourology and …, 2014 - Wiley Online Library
The pathophysiology of lower urinary tract symptoms (LUTS), particularly in the elderly,
seems to be multifactorial. One of the factors involved may be chronic ischemia of the …

Chronic bladder ischemia and oxidative stress: new pharmacotherapeutic targets for lower urinary tract symptoms

M Nomiya, KE Andersson… - International Journal of …, 2015 - Wiley Online Library
Chronic bladder ischemia is potentially a common cause of lower urinary tract symptoms in
the elderly. Epidemiological studies have shown a close association between lower urinary …

Bladder hyperactivity induced by oxidative stress and bladder ischemia: a review of treatment strategies with antioxidants

YH Wu, KS Chueh, SM Chuang, CY Long… - International Journal of …, 2021 - mdpi.com
Overactive bladder (OAB) syndrome, including frequency, urgency, nocturia and urgency
incontinence, has a significantly negative impact on the quality-of-life scale (QoL) and can …

A review of oxidative stress and urinary dysfunction caused by bladder outlet obstruction and treatments using antioxidants

Y Miyata, T Matsuo, K Mitsunari, A Asai, K Ohba… - Antioxidants, 2019 - mdpi.com
Urinary dysfunction is a common pathological condition that can significantly decrease the
quality of life. Bladder outlet obstruction (BOO) is a major cause of urinary dysfunction, and …

Do functional changes occur in the bladder due to bladder outlet obstruction?‐ICI‐RS 2018

R Bosch, P Abrams, MA Averbeck… - Neurourology and …, 2019 - Wiley Online Library
Studies on bladder dysfunction (BD), more specifically functional‐urodynamic changes in
the bladder as a result of bladder outlet obstruction (BOO) have been summarized for this …

Prophylactic effect of tadalafil on bladder function in a rat model of chronic bladder ischemia

M Nomiya, DM Burmeister, N Sawada, L Campeau… - The Journal of …, 2013 - Elsevier
PURPOSE: We investigated the effect of tadalafil on chronic ischemia related bladder
dysfunction. MATERIALS AND METHODS: Adult male Sprague-Dawley® rats were divided …

Hypoxia-induced HIF-1α expression promotes neurogenic bladder fibrosis via EMT and pyroptosis

Q Li, Y Hong, J Chen, X Zhou, X Tian, Y Yu, L Shen… - Cells, 2022 - mdpi.com
Background: Neurogenic bladder (NB) patients exhibit varying degrees of bladder fibrosis,
and the thickening and hardening of the bladder wall induced by fibrosis will further affect …

Latest treatment for lower urinary tract dysfunction: therapeutic agents and mechanism of action

O Yamaguchi - International journal of urology, 2013 - Wiley Online Library
Recent studies suggest that antimuscarinics might suppress bladder afferent activity by
blocking muscarinic receptors in the urothelium, myofibroblasts and detrusor, thereby …