Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play
important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are …

Monocyte Chemoattractant Protein-1 (MCP-1) is the first discovered and most extensively
studied CC chemokine, and the amount of studies on its role in the etiologies of obesity-and …

A host of diabetes-related insults to the central nervous system (CNS) have been clearly
documented in type-1 and-2 diabetic patients as well as experimental animal models. These …

A clear relationship between diabetes and cardiovascular disease has been established for
decades. Despite this, the mechanisms by which diabetes contributes to plaque formation …

Diabetic retinopathy (DR) is a well-known microvascular complication related to
inflammation. Mcc950 is a potent and specific inhibitor of the NLRP3 inflammasome but its …

Circulating apolipoprotein B-containing lipoproteins, notably the low-density lipoproteins,
enter the inner layer of the arterial wall, the intima, where a fraction of them is retained and …

The incidence of cardiovascular complications associated with hyperglycemia is a growing
global health problem. This review discusses the link between hyperglycemia and …

Glycation is the result of covalent bonding of a free amino group of biological
macromolecules with a reducing sugar, which results in the formation of a Schiff base that …

Disorders of lipoprotein metabolism and glucose homeostasis are common consequences
of insulin resistance and usually co-segregate in patients with metabolic syndrome and type …

Oxidative stress has been linked to the pathogenesis of the major complications of diabetes
in the kidney, the heart, the eye or the vasculature. NADPH oxidases of the Nox family are a …