Both ubiquitination and SUMOylation are dynamic post-translational modifications that
regulate thousands of target proteins to control virtually every cellular process …

Chromatin functions are influenced by the addition, removal, and recognition of histone post-
translational modifications (PTMs). Ubiquitin and ubiquitin-like (UBL) PTMs on histone …

Hundreds of E3 ligases play a critical role in recognizing specific substrates for modification
by ubiquitin (Ub). Separating genuine targets of E3s from E3-interactors remains a …

The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the
impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown …

Abstract Herpes simplex virus 1 (HSV-1) hijacks ubiquitination machinery to modify the
cellular proteome to create an environment permissive for virus replication. HSV-1 encodes …

Abstract The Retinoic acid-Inducible Gene I (RIG-I) like receptors (RLRs) are the major viral
RNA sensors essential for the initiation of antiviral immune responses. RLRs are subjected …

Abstract Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are two
neurodegenerative disorders that share genetic causes and pathogenic mechanisms. The …

Biomolecular condensates are membraneless organelles (MLOs) that form dynamic,
chemically distinct subcellular compartments organizing macromolecules such as proteins …

The fast dynamics and reversibility of posttranslational modifications by the ubiquitin family
pose significant challenges for research. Here we present SUMO-ID, a technology that …

Spatial organization of cellular processes in membranous or membrane-less organelles
(MLOs, alias molecular condensates) is a key concept for compartmentalizing biochemical …