Tumor angiogenesis is an essential process for supplying rapidly growing malignant tissues
with essential nutrients and oxygen. An angiogenic switch allows tumor cells to survive and …

Angiogenesis and lymphangiogenesis often occur in response to tissue injury or in the
presence of pathology (eg, cancer), and it is these types of environments in which …

The immunosuppressive tumor microenvironment (TME) represents a major barrier for
effective immunotherapy. Tumor-associated macrophages (TAMs) are highly heterogeneous …

Abstract Background Tumor-associated macrophages (TAMs) are classified into two major
phenotypes, M1 and M2. M1 TAMs suppress cancer progression, while M2 TAMs promote it …

CAFs (cancer-associated fibroblasts) are highly flexible cells of the cancer
microenvironment. They produce the extracellular matrix (ECM) constituents that form the …

The growing research interest in nanomedicine for the treatment of cancer and inflammatory-
related pathologies is yielding encouraging results. Unfortunately, enthusiasm is tempered …

Corneal transplantation is the most successful solid organ transplantation performed in
humans. The extraordinary success of orthotopic corneal allografts, in both humans and …

Using a bacterial pathogen–induced acute inflammation model in the skin, we defined the
roles of local lymphatic vessels and draining lymph nodes (DLNs) in antigen clearance and …

There are no conventional lymphatic vessels within the CNS parenchyma, although it has
been hypothesized that lymphatics near the cribriform plate or dura maintain fluid …

To trigger an effective immune response, antigen and antigen-presenting cells travel to the
lymph nodes via collecting lymphatic vessels. However, our understanding of the regulation …