Helminth infections and host immune regulation

HJ McSorley, RM Maizels - Clinical microbiology reviews, 2012 - journals.asm.org
Helminth parasites infect almost one-third of the world's population, primarily in tropical
regions. However, regions where helminth parasites are endemic record much lower …

A research agenda for helminth diseases of humans: the problem of helminthiases

S Lustigman, RK Prichard, A Gazzinelli… - PLoS neglected …, 2012 - journals.plos.org
A disproportionate burden of helminthiases in human populations occurs in marginalised,
low-income, and resource-constrained regions of the world, with over 1 billion people in …

Immunomodulation by helminth parasites: defining mechanisms and mediators

HJ McSorley, JP Hewitson, RM Maizels - International journal for …, 2013 - Elsevier
Epidemiological and interventional human studies, as well as experiments in animal
models, strongly indicate that helminth parasitic infections can confer protection from …

Chronic helminth infections induce immunomodulation: consequences and mechanisms

E van Riet, FC Hartgers, M Yazdanbakhsh - Immunobiology, 2007 - Elsevier
Worldwide, more than a billion people are infected with helminths. These worm infections
generally do not lead to mortality, however, they are chronic in nature and can lead to …

Wheezing, allergy, and parasite infection in children in urban and rural Ethiopia

D Dagoye, Z Bekele, K Woldemichael… - American journal of …, 2003 - atsjournals.org
Epidemiological studies in develo** countries suggest that intestinal parasite infection
may reduce the risk of asthma. Because this evidence is all derived from adults and older …

Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infection

HH Smits, H Hammad, M van Nimwegen… - Journal of Allergy and …, 2007 - Elsevier
BACKGROUND: Population studies have suggested that chronic and intense helminth
infections, in contrast to acute and mild helminth infections, might suppress allergic airway …

Do mouse models of allergic asthma mimic clinical disease?

MM Epstein - International archives of allergy and immunology, 2004 - karger.com
Experimental mouse models of allergic asthma established almost 10 years ago offered new
opportunities to study disease pathogenesis and to develop new therapeutics. These …

Schistosoma mansoni Antigens Modulate Experimental Allergic Asthma in a Murine Model: a Major Role for CD4+ CD25+ Foxp3+ T Cells Independent of …

LGG Pacífico, FAV Marinho, CT Fonseca… - Infection and …, 2009 - journals.asm.org
In areas where schistosomiasis is endemic, a negative correlation is observed between
atopy and helminth infection, associated with a low prevalence of asthma. We investigated …

Helminth infection with Litomosoides sigmodontis induces regulatory T cells and inhibits allergic sensitization, airway inflammation, and hyperreactivity in a murine …

AM Dittrich, A Erbacher, S Specht, F Diesner… - The journal of …, 2008 - journals.aai.org
Numerous epidemiological studies have shown an inverse correlation between helminth
infections and the manifestation of atopic diseases, yet the immunological mechanisms …

Regulation of allergy and autoimmunity in helminth infection

MS Wilson, RM Maizels - Clinical reviews in allergy & immunology, 2004 - Springer
Parasitic infections are a major theme in the “hygiene hypothesis”, as allergies and
autoimmune diseases are less prevalent in countries with higher burdens of helminths and …